Biotechnology and Health

Almeida L, Rocha JF, Falcão AC, Palma PN, Loureiro AI, Pinto R, Bonifácio MJ, Wright LC,  Nunes T. Soares-da-Silva P. (2013) Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects: Prediction of Slow Enzyme-Inhibitor Complex Dissociation of a Short-Living and Very Long-Acting Inhibitor. Clinical Pharmacokinetics, 52(2):139-151. Q1

Alves G, Rodrigues M, Fortuna A, Falcão AC, Queiroz J (2013) A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis. Bioanalysis, 5(11): 1409-1442. Q1

Bento D, Borchard G, Gonçalves T, Borges O. (2013) Validation of a new spectrophotometric method for the qualification of compound 48/80 associated with nanoparticles. AAPS PharSciTech. 14(2):649-655. IF: 1.9, Q1
Bicker J, Fortuna A, Alves G, Falcão AC. (2013) Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples–A review. Analytica Chimica Acta, 768: 12-34. Q1

Calejo MT, Cardoso AMS, Kjøniksena AL, Zhub K, Morais CM, Sandea SA, Cardoso AL, Pedroso de Lima MC,  Jurado A, Nyström B. (2013) Temperature-Responsive Cationic Block Copolymers as Nanocarriers for Gene Delivery. International Journal of Pharmaceutics 448 (1), 105-14. IF: 3.45, Q1

Calejo MT, Cardoso AMS, Marques EF, Araújo MJ, Kjøniksen AL, Sande SA, de Lima MCP, Jurado AS, and Nyström B. (2013) In vitro cytotoxicity of a thermoresponsive gel system combining ethyl(hydroxyethyl) cellulose and lysine-based surfactants. Colloids and Surfaces B: Biointerfaces 102 (0), 682-686. IF: 3.35, Q2

Cardoso AM, Trabulo S, Cardoso AL, Maia S, Gomes P, Jurado AlS, and Pedroso de Lima MC. (2013) Comparison of the Efficiency of Complexes Based on S413-PV Cell-Penetrating Peptides in Plasmid DNA and siRNA Delivery. Molecular Pharmaceutics 10 (7), 2653-2666. IF: 4.57, Q1

Correia D, Pereira C, Veríssimo P, Dourado A. (2013) A Platform for Peptidase Detection Based on Text Mining Techniques and Support Vector Machines. Computational Intelligence and Decision Making, 449-459.

Costa PM, Cardoso AL, Mendonça LS, Serani A, Custódia C, Conceição M, Simões S, Moreira JN, Pereira de Almeida L, Pedroso de Lima MC. (2013) Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment. Molecular Therapy  2:e100.  IF: 7.04, Q1

Costa PM, Cardoso AL, Nóbrega C, Pereira de Almeida LF, Bruce JN, Canoll P, and Pedroso de Lima MC. (2013) microRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma. Human Molecular Genetics,  22 (5) 904-18. IF: 7.69; Q1

Costa PM and Pedroso de Lima MC. (2013) MicroRNAs as molecular targets for cancer therapy: on the modulation of miRNA expression. Pharmaceuticals, 6(10):1195-1220.

Costa PM and Pedroso de Lima MC. (2013) Viral and non-viral gene therapy for glioblastoma: new insights into the treatment of malignant brain tumors. Journal of Genetic Syndromes & Gene Therapy, 4:161 .

Duarte S, Momier D, Baqué P, Casanova V, Loubat A, Samson M, Guigonis JM, Staccini P, Saint-Paul MC , Pedroso de Lima MC, Carle GF and Pierrefite Carle V.  (2013) Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model. Stem Cells, 31 423-432. IF: 7.7, Q1

Duarte SC, Almeida AM, Teixeira AS, Pereira AL, Falcão AC, Pena A, Lino CM. (2013) Aflatoxin M1 in marketed milk in Portugal: assessment of human and animal exposure. Food Control, 30:411-417. Q1

Falcão AC, Lima R, Sousa R, Nunes T, Soares-da-Silva P. (2013) Bioequivalence of Eslicarbazepine Acetate from Two Different Sources of its Active Product Ingredient in Healthy Subjects. Drugs in R&D, 13: 137-143.

Falcão AC, Pinto R, Nunes T, Soares-da-Silva P. (2013) Effect of repeated administration of eslicarbazepine acetate on the pharmacokinetics of simvastatin in healthy subjects. Epilepsy Research, 106: 244-249.

Falcão AC, Vaz-da-Silva M, Gama H, Nunes T,  Almeida L, Soares-da-Silva P. (2013) Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy women. Epilepsy Research, 105: 368-376.

Figueiredo S, Cutri JC, Rizzitelli S, De Luca E, Geraldes CF, Moreira JN, Aime S, Terreno E. (2012) MRI tracking of macrophages labeled with glucan particles entrapping a Water Insoluble Paramagnetic Gd-Based Agent. Molecular Imaging and Biology, (3):307-15 (2013).  IF: 3.844, Q1

Gil-Nager A, Elger C, Ben-Menachem E, Haláz P, Lopes-Lima J, Gabbai AA, Nunes T, Falcão AC, Almeida L, Soares-da-Silva P. (2013) Efficacy and safety of eslicarbazepine acetate as add‐on treatment in patients with focal‐onset seizures: Integrated analysis of pooled data from double‐blind phase III clinical studies. Epilepsia, 54(1):98-107. Q1

Gomes CP, Gomes-da-Silva LC, Ramalho JS, Pedroso de Lima MC, Simões S, Moreira JN. (2013) Impact of PLK-1 silencing on endothelial cells and cancer cells of diverse histological origin. Current Gene Therapy, 13(3):189-201. IF: 5.318; Q1

Gomes-da-Silva LC, Ramalho JS, Pedroso de Lima MC, Simões S, Moreira JN. (2013) Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform. European Journal of Pharmaceutics and Biopharmaceutics, 85(3 Pt A):356-364. IF: 3.826, Q1

Gomes-da-Silva LC, Fernández Y, Abasolo I, Schwartz Jr S, Ramalho JS, Pedroso de Lima MC, Simões S, Moreira JN. (2013) Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform. Nanomedicine, 8(9):1397-413.  IF: 5.26, Q1

Gomes RSM, Neves R, Cochlin L, Lima AF, Carvalho R, Korpisalo P, Dragneva G, Turunen M, Liimatainen T, Clarke K, Yla-Herttuala S, Carr CA, Ferreira L. (2013) Nanoparticles for simultaneous cell tracking and pro-survival/angiogenic miRNA delivery in an ischemic animal model. ACS Nano, 7(4), 3362-3372. IF: 12.0, Q1

Gonçalves D, Alves G, Fortuna A, Soares-da-Silva P, Falcão AC. (2013) HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma. Analyst, 138(8): 2463-2469. Q1
Guedes J, Cardoso AL, Pedroso de Lima MC. (2013) MicroRNA involvement in microglia-mediated immune response. Clinical and Developmental Immunology – Special Issue “Microglia in Development and Disease”.  article ID 186872. IF: 3.06, Q2

Hufnagel A, Menachem B, Gabbai AA, Falcão AC, Almeida L, Soares-da-Silva P. (2013) Long-term safety and efficacy of eslicarbazepine acetate as adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy: Results of a 1-year open-label extension study. Epilepsy Research, 103(2-3):262-269.

Jesus S, Borchard G, Borges O. (2013) Freeze dried chitosan/poly-epsilon-caprolactone and poly-epsilon-caprolactone nanoparticles: evaluation of their potential as DNA and antigen delivery system. Journal of Genetic Syndromes & Gene Therapy, 4:164.

Leal AS, Wang R, Salvador JAR, Jing YK. (2013) Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells. Org. Biomol. Chem. 11, 1726-1738. IF: 3.568, Q1

Lino MM*, Paulo CSO*, Vale AC, Vaz MF, Ferreira LS. (2013) Antifungal activity of dental resins containing amphotericin B-functionalized silica nanoparticles. Dental Materials, 29(10): e252-62. *Authors contributed equally. IF: 3.7, Q1

Monteiro JP, Martins AF, Nunes C, Morais CM, Lúcio, M, Reis S, Pinheiro TJT, Geraldes CFGC, Oliveira PJ, and Jurado AS. (2013) A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects. Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (8), 1899-1908. IF: 3.38, Q1

Monteiro JP, Oliveira PJ, and Jurado AS. (2013) Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions. Progress in Lipid Research 52 (4), 513-528. IF: 10.25, Q1

Moreira VM, Salvador JA, Simões S, Destro F, Gavioli R. (2013) Novel oleanolic vinyl boronates: synthesis and antitumor activity. Eur. J. Med. Chem. 63:46-56. IF:3,499, Q1

Morgado L, Pereira C, Veríssimo P, Dourado A. (2013) Efficient Discriminative Models for Proteomics with Simple and Optimized Features. Computational Intelligence and Decision Making, 89-98.

Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L. (2013) Beclin-1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. Brain DOI: 10.1093/brain/awt144. IF: 9.9, Q1

Nóbrega C*, Nascimento-Ferreira I*, Onofre I, Albuquerque D,  Hirai H, Déglon N,  Pereira de Almeida L.  (2013) Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice. PLoS ONE 8(1): e52396. doi:10.1371/journal.pone.0052396 *Equal contribution. DOI: 10.1371/journal.pone.0052396. IF: 3.7, Q1

Nóbrega C*, Nascimento-Ferreira I*, Onofre I, Albuquerque D, Conceição M, Déglon N,  Pereira de Almeida L. (2013) Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology. Cerebellum 12(4):441-55 doi:10.1007/s12311-012-0432-0. *Equal contribution. IF: 2.6, Q3

Nunes T, Rocha JF, Falcão AC, Almeida L, Soares-da-Silva P. (2013) Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers. Epilepsia, 54(1):108-116. Q1

Oliveira J, Correia D, Pereira C, Veríssimo P, Dourado A. (2013)A Tool for Biomedical–Documents Classification Using Support Vector Machines. Computational Intelligence and Decision Making, 407-416.

Paiva G, Proença DN, Francisco R,Veríssimo P, Santos S, Fonseca L, Abrantes IMO, Morais PV. (2013) Nematicidal Bacteria Associated to Pinewood Nematode Produce Extracellular Proteases. PLoS One 8(11):e79705 DOI: 10.1371/journal.pone.0079705.

Paulo CSO*, Lino MM*, Matos AA, Ferreira LS. (2013) Nanoparticles conjugated with amphotericin B are differentially taken up by human cells and after internalization increase the expression of heat shock protein. Biomaterials, 34(21), 5281-5293. *Authors contributed equally. IF: 7.6, Q1

Pereira MJ, Oyuang B, Sarkar D, Lang N, Sunbdback C, Fiehs I, Mureli S, Pometantseva I, McFaden J, Sehn JD, Mwizerwa O, del Nido P, Masiakos P, Langer R, Ferreira LS*, Karp JM*. (2013) A highly tunable elastomer for local and controlled release of macromolecular therapeutics. Advanced Materials, 25(8), 1209-1215. *Authors contributed equally. IF: 14.8, Q1

Ricotti L, Fujie T, Vazão H, Ciofani G, Filippeschi C, Corradini I, Matteoli M, Mattoli V, Ferreira L, Menciassi A. (2013) Boron nitride nanotube-mediated stimulation of cell co-culture on microengineered hydrogels. PLoS One 8(8), e71707. IF: 3.7, Q1

Rocha JF, Almeida L, Falcão AC, Nuno P, Loureiro AI,  Pinto R, Bonifácio MJ, Wright L, Nunes T, Soares-da-Silva P. (2013) Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects. British Journal of Clinical Pharmacology, 76(5): 763-775. Q1

Rodrigues AT, Roque F, Abrantes J, Falcão AC, Figueiras A, Herdeiro MT. (2013) Understanding physician antibiotic prescribing behaviour: a systematic review of qualitative studies. International Journal of Antimicrobial Agents, 41(3): 203-212.

Rodrigues M, Alves G, Abrantes J, Falcão AC. (2013) Herb-drug interaction of Fucus vesiculosus extract and amiodarone in rats: a potential risk for reduced bioavailability of amiodarone in clinical practice. Food and Chemical Toxicology, 52: 121-128. Q1

Rodrigues M, Alves G, Falcão AC. (2013) Investigating herb-drug interactions: the effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats. Food and Chemical Toxicology, 60: 153–159. Q1

Rodrigues M, Alves G, Rocha M, Queiroz J, Falcão AC. (2013) First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure. Journal of Chromatographic B, 913-914: 90-97.

Salvador JAR, Carvalho JFS,  Neves MAC, Silvestre MS, Leitão A J, Silva MMC,  Sá e Melo M L (2013) Anticancer steroids: linking natural and semi-synthetic compounds. Nat. Prod. Rep., 30 (2), 324-374. IF: 10.178, Q1

Salvador JAR, Pinto RMA, Silvestre SM. (2013) Steroidal 5 alpha-reductase and 17 alpha-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases. J. Steroid Biochem. Mol. Biol. 137, 199-222. IF: 3.984, Q2

Santos SM, Dinis AM, Peixoto F, Ferreira L, Jurado AlS, and Videira RA. (2013) Interaction of fullerene nanoparticles with biomembranes: from the partition in lipid membranes to effects on mitochondrial bioenergetics. Toxicological Sciences, IF: 4.32, Q1

Santos SM, Dinis AM, Rodrigues DM, Peixoto F, Videira RA, and Jurado AS. (2013) Studies on the toxicity of an aqueous suspension of C60 nanoparticles using a bacterium (gen. Bacillus) and an aquatic plant (Lemna gibba) as in vitro model systems. Aquat. Toxicol. 142-143 347-354. IF: 3.73, Q1

Silva SG, Alves C, Cardoso AMS, Jurado AS, Pedroso de Lima MC, Vale MLC, and Marques EF. (2013) Synthesis of Gemini Surfactants and Evaluation of Their Interfacial and Cytotoxic Properties: Exploring the Multifunctionality of Serine as Headgroup. European Journal of Organic Chemistry, (9), 1758-1769. IF: 3,4, Q1

Sousa J, Alves G, Campos G, Fortuna A, Falcão AC. (2013) First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma. Journal of Chromatography B, 930: 104-111.

Toubarro D, Avila MM, Hao YJ, Balasubramanian N, Jing Y, Montiel R, Faria TQ. Brito RMM, and Simões N. (2013) A Serpin Released by an Entomopathogen Impairs Clot Formation in Insect Defense System. PLoS One 8(7): e69161. IF: 3.730, Q1

Trabulo S, Cardoso AL, Cardoso AM, Morais CM, Jurado AS, and Pedroso de Lima MC. (2013) Cell penetrating peptides as nucleic acid delivery systems: from biophysics to biological applications. Current Pharmaceutical Design, 19 (16) 2895-923. IF: 3.3, Q1
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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