Almeida S, Laço M, Cunha-Oliveira T, Oliveira CR, Rego AC (2009) BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons. Neurobiol. Dis. 35: 448-456.

Álvaro AR, Rosmaninho-Salgado J, Ambrósio AF and Cavadas C (2009) Neuropeptide Y inhibits [Ca(2+)](i) changes in rat retinal neurons through NPY Y1, Y4 and Y5 receptors. J. Neurochem. 109:1508-1515.

Arduíno DM, Esteves AR, Pereira CF, Cardoso SM, Oliveira CR (2009) ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells. BMB Reports 42:719-724.

Arduíno DM, Esteves AR, Cardoso SM, Oliveira CR (2009) Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinsons disease. Neurochem. Int. 55:341-348.

Canas PM, Duarte JMN, Rodrigues RJ, Köfalvi A, Cunha RA (2009) Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiology of Aging 30, 1877-1884.

Canas PM, Porciúncula LO, Cunha GMA, Silva CG, Machado NJ, Oliveira JMA, Oliveira CR, Cunha RA (2009) Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by β-amyloid peptides via p38 mitogen-activated protein kinase pathway. Journal of Neuroscience 29 14741-14751 .

Costa G, Pereira T, Neto AM, Cristovao  AJ, Ambrosio AF, Santos  PF (2009) High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures. J Neurosci Res. 87:1375-1380.

Duarte AS, Duarte EP, Correia A, Pires E, Barros MT (2009) Cardosins improve neuronal regeneration after cell disruption: a comparative expression study. Cell Biol. Toxicol. 25:99-108.

Duarte JMN, Carvalho RA, Cunha RA, Gruetter R (2009) Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. Journal of Neurochemistry 111, 368-379.

Esteves ARF, Arduíno DM, Swerdlow RH, Oliveira CR, Cardoso SM (2009) Oxidative Stress potentiates alpha-synuclein oligomerization in PD Cybrids. Antioxi. Redox Signal. 11:439-448

Ferreira SG, Lomaglio T, Avelino A, Cruz F, Oliveira CR, Cunha RA, Köfalvi A (2009) N-acyldopamines control striatal input terminals via novel ligand-gated cation channels. Neuropharmacology 56, 676-683.

Fonseca AC, Proença T, Resende R, Oliveira CR, Pereira C (2009) Neuroprotective effects of statins in an in vitro model of Alzheimer’s disease. J Alzheimers Dis 17:503-517.

Gomes CARV, Simões PF, Canas PM, Quiroz C, Sebastião AM, Ferré S, Cunha RA, Ribeiro JA (2009) GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors. Journal of Neurochemistry 108, 1208-1219.

Macedo-Ribeiro S, Cortes L, Maciel P, and Carvalho AL (2009) Nucleocytoplasmic shuttling activity of ataxin-3. PLoS ONE 4, e5834.

Manadas B, Santos AR, Szabadfi K, Gomes JR, Garbis SD, Fountoulakis M, Duarte CB (2009) BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: protein levels and dendritic mRNA. J. Proteome Res. 8:4536-4552.

Nicoleau C, Benzakour O, Agasse F, Thiriet N, Petit J, Prestoz L, Roger M, Jaber M, Coronas V (2009) Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal. Stem Cells 27:408-419.

Nunes AF, Montero M, Franquinho F, Santos SD, Malva J, Zimmer J, Sousa MM (2009) Transthyretin knockout mice display decreased susceptibility to AMPA-induced neurodegeneration. Neurochem Int. 55:454-457.

Quiróz C, Luján R, Uchigashima M, Simões AP, Lerner TN, Borycz J, Kachroo A, Canas PM, Orru M, Schwarzschild MA, Rosin DL, Kreitzer AC, Cunha RA, Watanabe M, Ferré S (2009) Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. Scientific World Journal 9:1321-1344.

Ribeiro-Resende VT, Pimentel-Coelho PM, Mesentier-Louro LA, Mendez RM, Mello-Silva JP, Cabral-da-Silva MC, de Mello FG, de Melo Reis RA, Mendez-Otero R  (2009) Trophic activity derived from bone marrow mononuclear cells increases peripheral nerve regeneration by acting on both neuronal and glial cell populations. Neuroscience 159:540-549.

Rosmaninho-Salgado J, Araújo IM, Alvaro AR, Mendes AF, Ferreira L, Grouzmann E, Mota A, Duarte EP, Cavadas C (2009) Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide. J Neurochem. 109:911-922.

Salgado AJ, Sousa RA, Fraga JS, Pego JM, Silva BA, Malva JO, Neves NM, Reis RL, Sousa N (2009) Effects of Starch/Polycaprolactone-based Blends for Spinal Cord Injury Regeneration in Neurons/Glial Cells Viability and Proliferation. J. Bioact. Biocomp. Polymers 24:235-248.

Santiago AR, Gaspar JM, Baptista FI, Cristóvão AJ, Santos PF, Kamphuis W and Ambrósio AF (2009) Diabetes changes the levels of ionotropic glutamate receptors in the rat retina. Mol. Vis. 15:1620-1630.

Santos RX, Cardoso S, Silva S, Correia S, Carvalho C, Crisóstomo J, Rodrigues J, Amaral C, Louro T, Matafome P, Santos MS, Duarte AI, Seiça R, Moreira PI (2009) Food deprivation promotes oxidative imbalance in rat brain. J. Food Sci. 74:H8-H14.

Santos SD, Carvalho AL, Caldeira MV, Duarte CB (2009) Regulation of AMPA receptors and synaptic plasticity. Neurosci. 158:105-125.

Silva AC, Pereira J, Oliveira CR, Bettencourt-Relvas J, Rego AC (2009) BDNF and extracellular matrix regulate the differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype. J. Neurosci. Res. 87: 1986-1996.

Velloso NA, Dalmolin GD, Gomes GM, Rubin MA, Canas PM, Cunha RA, Mello CF (2009) Spermine improves recognition memory deficit in a rodent model of Huntingtons disease. Neurobiology of Learning and Memory 92, 574-580.


Biotechnology and Health

Cardoso T, Oliveira C, Sarmento AC, Pereira A, Nutley MA, Jess T, Kelly SM, Cooper A, Price NC, Pires E, Barros M  (2009) Acetonitrile-induced unfolding of porcine pepsin A. A proposal for a critical role of hydration structures in conformational stability. Int J Biol Macromol. 1;45(3):213-20.

Carvalho JF, Cruz Silva MM, Moreira JN, Simões S, Sá E Melo ML (2009) Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols, J Med Chem, 9;52(13):4007-19.

Coelho PMBM, Salvador A, Savageau MA (2009) Quantifying Global Tolerance of Biochemical Systems: Design Implications for Moiety-Transfer Cycles. PLoS Comput. Biol. 5:e1000319.

Duarte AS, Duarte EP, Correia A, Pires E, Barros MT. (2009) Cardosins improve neuronal regeneration after cell disruption: a comparative expression study. Cell Biol Toxicol. (2):99-108.

Faneca H, Figueiredo VA, Tomaz I, Gonçalves G, Avecilla F, Pedroso de Lima MC, Geraldes CF, Pessoa JC, Castro MM. (2009) Vanadium compounds as therapeutic agents: some chemical and biochemical studies. J Inorg Biochem. 103(4):601-8.

Ferreira L (2009) Nanoparticles as tools to study and control stem cells. Journal of Cellular Biochemistry 108(4), 746-752.

Ferreira L*, Zumbuehl* (2009) Non-leaching surfaces capable of killing microorganisms on contact. Journal of Materials Chemistry 19, 7796-7806. *Corresponding author.

Ferreira PG, Silva CG, Azevedo PJ, and Brito RMM (2009) Spatial Clustering of Molecular Dynamics Trajectories in Protein Unfolding Simulations. Lecture Notes in Computer Science 5488, 156-166 (doi: 10.1007/978-3-642-02504-4).

Kraehenbuehl TP, Ferreira LS, Zammaretti P, Hubbell JA, Langer R (2009) Cell-responsive hydrogel for encapsulation of vascular cells”. Biomaterials 30(26), 4318-4324.

Moreira C, Oliveira H, Pires LR, Simões S, Barbosa MA, Pêgo AP, (2009) Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone. Acta Biomater, 5(8):2995-3006.

Neves S, Faneca H, Bertin S, Konopka K, Düzgünes N, Pirrefite-Carle V, Simões S and Pedroso de Lima MC (2009) Anti-tumoral effect of thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy mediated by transferrin-associated lipoplexes in an in vivo animal model for oral carcinoma:  Mechanisms involved in the therapeutic response. Cancer Gene Therapy, 16, 91–101.

Penacho N, Simões S, de Lima MC (2009) Polyethylenimine of various molecular weights as adjuvant for transfection mediated by cationic liposomes. Mol Membr Biol. 26(4):249-63.

Pereira M, Costa VS, Camacho R, Fonseca NA, Simões C, and Brito RMM (2009) Comparative Study of Classification Algorithms Using Molecular Descriptors in Toxicological DataBases. Lecture Notes in Bioinformatics 5676, 121-132 (doi: 10.1007/978-3-642-03223-3).

Pinto AC, Moreira JN, Simões S (2009) Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner, Cancer Chemother Pharmacol. 64(3):445-54.

Savageau MA, Coelho PMBM, Fasani RA, Tolla DA, Salvador A (2009) Phenotypes and tolerances in the design space of biochemical systems. Proc. Natl. Acad. Sci. USA 106: 6435–6440.


Cell and Molecular Toxicology

Almeida L, Falcão AC, Vaz-da-Silva M, Soares E, Costa R, Loureiro A, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, Soares-da-Silva P (2009) Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Molecular Nutrition and Food Research. 53 (Suppl. 1): 7-15.

Alves E, Summavielle T, Alves CJ, Custódio JB, Fernandes E, de Lourdes Bastos M, Tavares MA, Carvalho F (2009) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addict Biol. 14(2):185-93.

Alves G, Fortuna A, Falcão A (2009) Drug discovery and development process: bioanalytical framework supporting pharmacokinetic studies. International Journal of Medical and Biological Frontiers. 15:1043-1062.

Alves MG, Oliveira PJ, Carvalho RA (2009) Cardiac Mitochondrial Preservation in Celsior versus Histidine Buffer Solutions During Ischemia and Ischemia/Reperfusion. Cardiovasc. Toxicol. 9 (4): 185-193. 

Amaral S, Mota P, Lacerda B, Alves M, Pereira ML, Oliveira PJ, Ramalho-Santos J (2009) Testicular Mitochondrial Alterations in Untreated Streptozotocin-induced Diabetic Rats, Mitochondrion 9(1):41-50.

Ascensão A, Lumini-Oliveira J, Pereira CV, Aleixo I, Oliveira PJ, Magalhães J (2009) Endurance Training Improves Gastrocnemius Mitochondrial Function Despite Increased Susceptibility to Permeability Transition.  Mitochondrion, 9(6): 454-462.

Brito PM, Devillard R, Nègre-Salvayre A, Almeida LM, Dinis TCP, Salvayre R and Auge N (2009) Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis, 205, 126-134.

Cardoso S, Correia S, Santos RX, Carvalho C, Santos MS, Oliveira CR, Perry G, Smith MA, Zhu X, Moreira PI (2009) Insulin is a two-edged knife on the brain. J. Alzheimers Dis. 18;483-507.

Cardoso S, Santos R, Correia S, Carvalho C, Zhu X, Li H, Casadesus G, Smith M, Perry G, Moreira P (2009) Insulin and insulin-sensitizing drugs in neurodegeneration: mitochondria as therapeutic targets. Pharmaceuticals, 2, 250-286.

Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, Moreira PI (2009) Doxorubicin: the good, the bad and the ugly effect. Curr. Med. Chem. 16:3267-85.

Castel-Branco MM, Alves GL, Figueiredo IV, Falcão AC, Caramona MM (2009) The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs. Methods & Findings in Experimental & Clinical Pharmacology. 31:101-106.

Coelho JFJ, Gois J, Fonseca AC, Carvalho RA, Popov AV, Percec V, Gil MH (2009) Synthesis of poly(2-methoxyethyl acrylate) by single electron transfer – degenerative transfer living radical polymerization catalyzed by Na2S2O4 in water. J. Polymer Sci. A – Polymer Chem. 47:4454-4463.

Costa VM, Ferreira LM, Branco PS, Carvalho F, Bastos ML, Carvalho RA, Carvalho M, Remião F (2009) Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes. Chem. Res. Toxicol. 22:129-135.

Costa VM, Silva R, Amado F, Carvalho F, Bastos ML, Carvalho RA, Carvalho M, Remião F (2009) Redox behaviour of adrenaline under pro-oxidant conditions disrupts intracellular signalling pathways in freshly isolated cardiomyocytes. Toxicology 257: 70-79.

Costa VM, Silva R, Tavares LC, Vitorino R, Amado F, Carvalho F, Bastos ML, Carvalho M, Carvalho RA, Remião F (2009) Adrenaline incubation disrupts proteome homeostasis and alters mitochondrial activity and overall glucose metabolism in freshly isolated cardiomyocytes. Toxicology 260:84-96.

Custódio JB, Cardoso CM, Santos MS, Almeida LM, Vicente JA, Fernandes MA (2009) Cisplatin impairs rat liver mitochondrial functions by inducing changes on membrane ion permeability: prevention by thiol group protecting agents. Toxicology 259(1-2):18-24.

Diculescu VC, Enache TA, Oliveira PJ, Oliveira-Brett AM (2009) Electrochemical Oxidation of Berberine and of its Oxidation Products at a Glassy Carbon Electrode. Electroanalysis, 21 (9): 1027-1034.

Diculescu VC, Enache TA, Oliveira PJ, Oliveira-Brett AM (2009) Electrochemical Oxidation of Sanguinarine and of its Oxidation Products at a Glassy Carbon Electrode – Relevance to Intracellular Effects. Electroanalysis 22 (1): 113-120.

Diogo CV, Félix L, Vilela S, Burgeiro A, Barbosa IA, Carvalho MJ, Oliveira PJ, Peixoto F (2009) Mitochondrial Toxicity of the Phytochemicals Daphnetoxin and Daphnoretin – Relevance for Possible Anti-cancer Application. Tox. In Vitro 23(5):772-729.

Duarte JMN, Carvalho RA, Cunha RA, Gruetter R (2009) Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. J. Neurochem. 111:368-379.

Fernandes MA, Santos MS, Moreno AJ, Chernova L, Krauze A, Duburs G, Vicente JA. Effects of 5-acetyl(carbamoyl)-6-methylsulfanyl-1,4-dihydropyridine-5-carbonitriles on rat liver mitochondrial function. Toxicol. In Vitro. 23(7): 1333-41.

Frade JG, Barbosa RM and Laranjinha J (2009) Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices. Hippocampus, 19, 603-611.

Justino LLG, Ramos ML, Abreu PE, Carvalho RA, AJFN Sobral, Scherf U, Burrows HD (2009) Conformational studies on poly(9,9-dialkylfluorene)s in solution using NMR spectroscopy and density functional theory calculations. J. Phys. Chem. B 113:11808-11821.

Machado N, Alves M, Carvalho RA, Oliveira PJ (2009) Mitochondrial Involvement in Cardiac Apoptosis During Ischemia and Reperfusion – Can We Close the Box? Cardiovasc. Toxicol. 9 (4): 211–227.

Maia J, Coelho S, Lavrador I, Ventura C, Carvalho RA, Correia IJ, Gil MH (2009) Cellular adhesion and viability assessment on oxidized dextran-based hydrogels. Acta Biomaterialia 5:1948-1955.

Mota PC, Amaral SC, Martins L, Pereira ML, Oliveira PJ, Ramalho-Santos J (2009) Mitochondrial Bioenergetics of Testicular Cells from the Domestic Cat (Felis catus) - A Model for Endangered Species. Reprod.Toxicol. 27(2):111-116

Neves MAC, Dinis TCP, Colombo G and Sá e Melo ML (2009) An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. European Journal of Medicinal Chemistry 44, 4121-4127.

Neves MAC, Dinis TCP, Colombo G and Sá e Melo ML (2009) Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. Journal of Medicinal Chemistry 52, 143-150.

Nunes T, Almeida L, Rocha JF, Falcão AC, Fernandes-Lopes C, Loureiro AI, Wright L, Vaz-da-Silva M, Soares-da-Silva P (2009) Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and Young subjects. Journal of Clinical Pharmacology 49: 1477-1482.

Nunes T, Machado R, Rocha JF, Fernandes-Lopes C, Costa R, Torrão L, Loureiro AI, Falcão AC, Vaz-da-Silva M, Wright L, Almeida L, Soares-da-Silva P (2009) Pharmacokinetic-pharmacodynamic interaction between Nebicapone and Controlled-Release Levodopa/Benzserazide: a single-center, phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects. Clinical Therapeutics 31(10): 1-14.

Pereira CV, Moreira AC, Pereira SP, Machado NG, Carvalho FS, Sardão VA, Oliveira PJ (2009) Mitochondria: The New Comeback of an Old Biosensor for Drug Safety. Curr. Drug Safety 4(1):34-54.

Pereira SP, Fernandes MA, Martins JD, Santos MS, Moreno AJ, Vicente JA, Videira RA, Jurado AS. Toxicity assessment of the herbicide metolachlor comparative effects on bacterial and mitochondrial model systems. Toxicol In Vitro 23(8):1585-90.

Pereira SP, Pereira GC, Moreno AJ, Oliveira PJ (2009) Can We Predict Drug Safety and Reduce Animal Experiments by Using Isolated Mitochondrial Fractions as a Toxicity Biosensor? ATLA 37(4):355-365

Pinto MFV, Morán MC, Miguel MG, Lindman B, Jurado AS, Pais A. A. C. C. (2009). Controlling the morphology in DNA condensation and precipitation. Biomacromolecules10: 1319-1323.

Pinto RMA, Salvador JAR, Le Roux C, Carvalho RA, Matos Beja A, Paixão JA. (2009) Bismuth(III) triflate-catalyzed rearrangement of 16alpha,17alpha-epoxy-20-oxosteroids. Synthesis and structural elucidation of new 16alpha-substituted alpha-alkyl-17beta-methyl-delta13-18-norsteroids. Tetrahedron Lett. 65:6169-6178.

Pires A, Fortuna A, Alves G, Falcão A. (2009) Intranasal Drug Delivery: How, Why and What for? Journal of Pharmacy and Pharmaceutical Sciences. 12:288-311.

Rocha, BS, Gago, B, Barbosa RM and Laranjinha J. (2009) Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology, 265, 41-48.

Rocha JF, Falcão AC, Almeida L, Santos AT, Nunes T, Vaz-da-Silva M, Martins F, Fontes-Ribeiro C, Macedo T, Soares-da-Silva P (2009) Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics. 47(4): 255-261.

Rodrigues CFD, Urbano AM, Matoso E, Carreira I, Almeida A, Santos P, Botelho F, Carvalho L, Alves M, Monteiro C, Costa AN, Moreno V, Alpoim (2009) Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability. Mutat. Res. 670: 42-52.

Rodrigues C, Almeida A, Carreira IM, Matoso E, Urbano AM, Botelho MF, Carvalho L, Alves M, Monteiro C, Alpoim MC (2009) Hexavalent chromium and lung cancer: new perspectives. The FEBS J. 276: 339

Roleira FMF, Borges F, Andrade LCR, Paixão JA, Almeida MJM, Carvalho RA, Tavares da Silva EJ. (2009) Activation of hydrocinnamic acids with pentafluorophenol versus entafluorothiophenol. Reactivity towards hexylamine. J. Fluorine Chem. 130:169-174.

Rolo AP, Palmeira CM, Cortopassi GA. (2009) Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal Biochem. 385(1): 176-178.

Rolo AP, Teodoro JS, Peralta C, Rosello-Catafau J, Palmeira CM. (2009) Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: the key role of ATPsynthase and mitochondrial permeability transition. Transpl Int. 22(11): 1081-1090.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB.(2009) Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol. 64(4): 811-827.

Soares AF, Viega FJ, Carvalho RA, Jones JG. (2009) Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal and ad-libitum feeding conditions. Magn. Res. Med. 61: 1-5.

Tavares RS, Martins F, Oliveira PJ, Ramalho-Santos J, Peixoto F (2009) Parabens in Male Infertility – Is There a Mitochondrial Connection? Reprod.Toxicol. 27(1):1-7

Vaz-da-Silva M, Costa R, Soares E, Maia J, Falcão AC, Almeida L, Soares-da-Silva P (2009) Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects. Fundamental and Clinical Pharmacology. 23: 509-514.


Microbiology

Albuquerque L, Ferreira C, Tomaz D, Tiago I, Veríssimo A, da Costa MS, Nobre MF (2009) Meiothermus rufus sp. nov., a new slightly thermophilic red-pigmented species and emended description of the genus Meiothermus. Syst. Appl. Microbiol. 32:306-313.

Hipólito E, Faria A, Alves AF, de Hoog S, Anjos A, Gonçalves T, Morais AV, Estevão H (2009) Alternaria infectoria brain abcess in a child with Chronic Granulomatous Disease. European Journal of Clinical Microbiology and Infectious Diseases 28: 377-380.

Moe WM, Yan J, Nobre MF, da Costa MS, Rainey FA (2009) Dehalogenimonas lykanthroporepellens gen. nov., sp. nov., a reductively dehalogenating bacterium isolated from chlorinated solvent-contaminated groundwater. Int. J. Syst. Evol. Microbiol. 59:2692-2697.

Paulo, C, Marques, JM Mourão, G Rocha, AF Alves, M Meliço-Silvestre, A, Querol, C Clemente, O Flores, I Santos, Gonçalves, T (2009) Retrospective analysis of clinical yeast isolates in a hospital in the centre of Portugal: spectrum and revision of the identification procedures. Medical Mycology 47: 836-844.

Taborda M, Antunes A, Tiago I, Veríssimo A, Nobre MF, da Costa MS. (2009) Description of Idiomarina insulisalsae sp. nov., isolated from the soil of a sea salt evaporation pond, proposal to transfer the species of the genus Pseudidiomarina to the genus Idiomarina and emended description of the genus Idiomarina. Syst. Appl. Microbiol. 32:371-378.


Biophysics and Biomedical NMR

Burrows HD, Tapia MJ, Fonseca SM, Valente AJM, Lobo VMM, Justino LLG, Qiu S, Pradhan S, Scherf U, Chattopadhyay N, Knaapila M, Garamus VM. (2009)  Aqueous Solution Behavior of Anionic Fluorene-co-thiophene-Based Conjugated Polyelectrolytes, ACS Applied Materials & Interfaces, 1: 864-874.

Delgado TC, Pinheiro D, Caldeira M, Castro M, Geraldes C, Lopez-Larrubia P, Cérdan S,  Jones JG. (2009) Mechanisms of hepatic triglyceride accumulation during high-fat feeding in the healthy rat. NMR in Biomedicine 22: 310-317.

Delgado TC, Pinheiro D, Caldeira M, Castro MMCA, Geraldes CFGC, Lopez-Larrubia P, Cérdan S, Jones JG. (2009) Mechanisms of Hepatic Triglyceride Accumulation During High-Fat Feeding in the Healthy Rat. NMR in Biomedicine, 22: 310-317.

Delgado TC, Silva C, Fernandes I, Caldeira M, Bastos M, Baptista C, Carvalheiro M, Geraldes C, Jones JG  (2009)  Sources of hepatic glycogen synthesis during an oral glucose tolerance test: effect of transaldolase exchange on flux estimates.  Magn. Res. Med. 62: 1120-1128.

Geraldes CFGC, Laurent S. (2009) Classification and Basic Properties of Contrast Agents for Magnetic Resonance Imaging. Contrast Media Mol. Imaging, 4: 1-23.

Jones JG, Garcia P, Barosa C, Delgado TC, Diogo L. (2009) Hepatic anaplerotic outflow fluxes are redirected from gluconeogenesis to lactate synthesis in patients with Type 1a Glycogen Storage Disease. Metabolic Engineering 11: 155-162.

Justino LLG, Ramos ML, Abreu PE, Carvalho RA, AJFN Sobral, Scherf U, Burrows HD. (2009) Conformational studies on poly(9,9-dialkylfluorene)s in solution using NMR spectroscopy and density functional theory calculations. J Phys Chem B 113: 11808-11821.

Justino LLG, Ramos ML, Kaupp M, Burrows HD, Fiolhais C, Gil VMS. (2009) Density functional theory study of the oxoperoxo vanadium(V) complexes of glycolic acid. Structural correlations with NMR chemical shifts, Dalton Trans., 43: 9735-9745.

Kotková Z, Pereira GA, Djanashvili K, Kotek J, Rudovský J, Hermann P, Vander Elst L, Muller RN, Geraldes CFGC, Lukeš I, Peters JA (2009) Lanthanide(iii) complexes of phosphonic acid monoester and phosphinic acid analogues of H4DOTA as model compounds for evaluation of the second-sphere hydration. Eur. J. Inorg.Chem.: 119–136.

Nunes PN, Jones JG (2009)  Quantifying endogenous glucose production and contributing source fluxes from a single 2H NMR Spectrum.  Magn. Res. Med. 62:  802-807.

Faneca H, Figueiredo VA, Tomaz I, Gonçalves G, Avecilla F, Pedroso de Lima MC, Geraldes Carlos FGC, Pessoa JC, Castro MMCA (2009) Vanadium compounds as therapeutic agents: some chemical and biochemical studies. J. Inorg. Biochem., 103: 601-608.

Ferreira MF, Martins AF, Martins JA, Ferreira PM, Tóth É, Geraldes CFGC. (2009) Gd(DO3A-N-α-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents. Chem. Commun.: 6475-6477.

Fonseca CP, Sierra A, Geraldes CFGC, Cerdán S,  Castro MMCA (2009) Mechanisms underlying Li+ effects in glutamatergic and gabaergic neurotransmissions in the adult rat brain and in primary cultures of neural cells as revealed by 13C NMR. J. Neuroscience Res., 87: 1046–1055 (2009).

Pereira GA, Ball L, Sherry AD, Peters JA, Geraldes CFGC. (2009) NMR Characterization of Ln3+ Complexes of Tetraazaphosphinate and Phosphonate Ligands. Helv. Chim. Acta, 92: 2532-2551.

Pereira RFP, Valente AJM, Burrows HD, Ramos ML, Ribeiro ACF, Lobo VMM. (2009)  Flocculation and micellization of sodium dodecyl sulfate solutions in the presence of aluminium nitrate: effect of concentration and temperature. Acta Chimica Slovenica, 56:  45-52.

Polášek M, Hermann P, Peters JA, Geraldes CFGC, Lukeš I. (2009) PAMAM dendrimers conjugated with an uncharged gadolinium(iii) chelate with a fast water exchange: the influence of chelate charge on rotational dynamics. Bioconj. Chem., 20: 2142–2153.

Ramos ML., Justino LLG, Gil VMS, Burrows HD. (2009) NMR and DFT studies of the complexation of W(VI) and Mo(VI) with 3-phospho-D-glyceric and 2-phospho-D-glyceric acids, Dalton Trans., 43: 9616-9624.

Rodrigues CFD, Urbano AM, Matoso E, Carreira I, Almeida A, Santos P, Botelho F, Carvalho M, Alves M, Monteiro C, Costa A N, Moreno V., Alpoim MC. (2009) Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 670: 42-52.

Rodrigues TB, Fonseca CP, Castro MMCA, Cerdán S, Geraldes CFGC (2009) 13C NMR Tracers in Neurochemistry: Implications for Molecular Imaging. The Quarterly J. of Nucl. Med. and Molecular Imaging, 53: 631-645.

Silvério S, Torres S, Martins AF, Martins JA, André JP, Helm L, Prata MIM, Santos AC, Geraldes CFGC. (2009) (bis)-Hydroxymethyl-substituted DTTA skeleton: a new lead for the synthesis of high relaxivity MRI contrast agents? Dalton Trans.: 4656-4670.

Soares AF, Viega FJ, Carvalho RA, Jones JG. (2009) Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal and ad-libitum feeding conditions. Magn. Res. Med. 61: 1-5.


Cell and Development Biology

Amaral S, Mota, Lacerda B, Alves M, Pereira ML, Oliveira, PJ, Ramalho-Santos J. (2009) Testicular mitochondrial alterations during untreated streptozotocin-induced type 1 diabetes. Mitochondrion 9: 41-50.

Amaral S, Ramalho-Santos J. (2009) Aging, mitochondria and male reproductive function. Cur.Aging Sci. 2: 165-173.

Caetano-Lopes J, Nery AM, Henriques R, Canhão H, Duarte J, Amaral PM, Vale M, Moura RA, Pereira PA, Weinmann P, Abdulghani S, Souto-Carneiro M, Rego P, Monteiro J, Sakagushi S, Queiroz MV, Konttinen YT, Graça L, Vaz MF, Fonseca JE (2009) Chronic arthritis directly induces quantitative and qualitative bone disturbances leading to compromised biomechanical properties. Clin Exp Rheumatol. 27(3):475-82.

Cardoso CM, Groth-Pedersen L, Høyer-Hansen M, Kirkegaard T, Corcelle E, Andersen JS, Jäättelä M, Nylandsted J. (2009) Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. PLoS One. 4(2):e4424.

Cardoso CM, Jordao L, Vieira O.V. (2009) Rab10 Regulates Phagosome Maturation and Its Overexpression Rescues Mycobacterium-Containing Phagosomes Maturation. Traffic. [Epub ahead of print]

Gamboa S, Machado-Faria M, Ramalho-Santos J (2009) Seminal traits, suitability for semen preservation and fertility in the native Portuguese breeds Puro Sangue Lusitano and Sorraia: Implications for stallion classification and assisted reproduction. Animal Reprod. Sci.113:102-113.

Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason M, Heidersbach A, Ramalho-Santos J, McManus MT, Plath K, Meshorer E, Ramalho-Santos M. (2009) Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature  460: 863-868.

Martins TC. (2009) Mycobacteria and autoimmunity: the two sides of a coin. Curr. Topics on the Profiles of Host Immunological Response to Mycobacterial Infections. Chapter 7. Research Signpost.

Mota PC, Amaral S, Martins L, Oliveira, PJ, Ramalho-Santos J. (2009) Characterization of mitochondrial bioenergetics of domestic cat (Felis catus) testicular cells as a model for endangered carnivores. Reprod. Tox.  27: 111-116.

Neves BM, Cruz MT, Francisco V, Garcia-Rodriguez C, Silvestre R, Cordeiro-da-Silva A, Dinis AM, Batista MT, Duarte CB, Lopes MC. (2009) Differential roles of PI3-Kinase, MAPKs and NF-kappaB on the manipulation of dendritic cell T(h)1/T(h)2 cytokine/chemokine polarizing profile. Mol Immunol. 46:2481-92.

Nobre RJ, Herráez-Hernández E, Fei JW, Langbein L, Kaden S, Gröne HJ, de Villiers EM. (2009) E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures. J Virol. 83:2907-16.

Pereira MJ, Carvalho E, Eriksson J, Crans DC and Aureliano M (2009) Decavanadate and insulin mimetic vanadium compounds effects on adipocytes glucose uptake, JIB, 103(12):1687-92.

Ramalho-Santos J, Varum S, Amaral S, Mota PC, Sousa AP, Amaral A. (2009) Mitochondrial functionality and reproduction: From gonads and gametes to embryos and embryonic stem cells. Hum Reprod. Update 5: 553-572.

Rodrigues AS, Sarmento Ribeiro AB, Ramos F et al. (2009) Development of an analytical methodology for simultaneous determination of vincristine and doxorubicin in pharmaceutical preparations for oncology by HPLC-UV. J Chromatograph Sci.; 47: 387-391.

Rosa SC, Gonçalves J, Judas F, Lopes MC, Mendes AF (2009) Assessment of strategies to increase chondrocyte viability in cryopreserved human osteochondral allografts: evaluation of the glycosylated hydroquinone, arbutin. Osteoarthritis Cartilage. 17:1657-61.

Rosa SC, Gonçalves J, Judas F, Mobasheri A, Lopes MC, Mendes AF (2009) Impaired GLUT-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Res Ther. 11: R80.

Sousa AP, Tavares RS, Velez de la Calle JF, Figueiredo H, Almeida V, Almeida-Santos T, Ramalho-Santos J. (2009) Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin status. Hum. Reprod. 24:28-36.

Souto-Carneiro MM, Mahadevan V, Takada K, Fritsch-Stork R, Nanki T, Brown M, Fleisher TA, Wilson M, Goldbach-Mansky R, Lipsky PE (2009) Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor. Arthritis Res Ther.11(3):R84.

Tavares RS, Martins FC, Oliveira PJ, Ramalho-Santos J, Peixoto FP. (2009) Parabens in male infertility:Is there a mitochondrial connection? Reprod. Tox. 27: 1-7.

Tellechea A, Leal E, Veves A and Carvalho E. (2009) Neurovascular complications in  diabetic wound healing. The Open Circulation & Vascular Journal, 2:

Varum S, Momcilovic O, Castro C, Ben-Yehudah A, Ramalho-Santos J*, Navara CS* (2009) Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain. Stem Cell Res. 3: 142-156. *co-corresponding authors