Agasse F, Bernardino L, Kristiansen H, Christiansen SH, Ferreira R, Silva B, Grade S, Woldbye DP and Malva JO (2008) Neuropeptide Y Promotes Neurogenesis in Murine Subventricular Zone. Stem Cells 26: 1636-1645.

Agasse F, Bernardino L, Silva B, Ferreira R, Grade S and Malva JO (2008) Response to histamine allows the functional identification of neuronal progenitors, neurons, astrocytes and immature cells in subventricular zone cell cultures. Rejuvenation Res. 11:187-200.

Agostinho P, Lopes JP, Velez Z, Oliveira CR (2008) Overactivation of calcineurin induced by amyloid-beta and prion proteins. Neurochem. Int. 52, 1226-1233.

Almeida S, Sarmento-Ribeiro AB, Januário C, Rego AC, Oliveira CR (2008) Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntingtons disease patients. Biochem. Biophys. Res. Commun. 374, 599-603.

Álvaro AR, Martins J, Costa AC, Fernandes E, Carvalho F, Ambrósio AF, Cavadas C (2008) Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy. Neuroscience 152:97-105.

Álvaro AR, Martins J, Araújo IM, Rosmaninho-Salgado J, Ambrósio AF, Cavadas C (2008) Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide. J Neurochem 105:2501-2510.

Araújo IM, Gil J, Carreira BP, Mohapel P, Petersén Å, Pinheiro PS, Soulet D, Bahr BA, Brundin P, Carvalho CM (2008) Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus. J. Neurochem. 105:666-676.

Arduíno D, Silva D, Cardoso SM, Chaves S, Oliveira CR, Santos MA (2008) Synthesis and investigation of new hydroxypyridinone based iron-chelators as potential anti-neurodegenerative drug candidates. Front. Biosci. 13,6763-6774.

Bernardino L, Agasse F, Silva B, Ferreira R, Grade S and Malva JO (2008) Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures. Stem Cells 26: 2361-2371.

Bernardino L, Balosso S, Ravizza T, Marchi N, Ku G, Randle JC, Malva JO and Vezzani A (2008) Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X(7) receptor-mediated IL-1beta release. J. Neurochem. 106: 271-280.

Canas PM, Duarte JM, Rodrigues RJ, Köfalvi A, Cunha RA (2008) Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiol. Aging 25.

Cardoso S, Santos RX, Carvalho C, Correia S, Pereira GC, Pereira SS, Oliveira PJ, Santos MS, Proença T, Moreira PI (2008) Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage. Free Radic. Biol. Med. 45, 1395-1402.

Carvalho AL, Caldeira MV, Santos SD, Duarte CB. (2008) Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br. J. Pharmacol. 153 Suppl 1:S310-24.

Correia S, Carvalho C, Santos MS, Proença T, Nunes E, Duarte AI, Monteiro P, Seiça R, Oliveira CR, Moreira PI (2008) Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med. Chem. 4:358-364.

Cunha GM, Canas PM, Melo CS, Hockemeyer J, Müller CE, Oliveira CR, Cunha RA (2008) Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. Exp. Neurol. 210:776-81.

Cunha-Oliveira T, Rego AC, Oliveira CR (2008) Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res Rev. 58:192-208.

Cunha RA, Ferré S, Vaugeois JM, Chen JF (2008) Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Curr. Pharm. Des. 14:1512-24.

Domingues AF, Arduíno DM, Esteves ARF, Swerdlow RH, Oliveira CR, Cardoso SM (2008) Mitochondria and Ubiquitin Proteasomal System interplay in Parkinsons disease. Free Radic. Biol. Med. 45:820-825.

Domingues AF, Esteves ARF, Swerdlow RH, Oliveira CR, Cardoso SM (2008) Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells. Neurotox. Res. 13,31-88.

Donato R, Rodrigues RJ, Takahashi M, Tsai MC, Soto D, Miyagi K, VillafuertesRG, Cunha RA, Edwards FA. (2008) GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx. Cell Calcium. 44:521-32.

Duarte AI, Santos P, Oliveira CR, Santos MS, Rego AC (2008) Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression. Biochem Biophys Acta – Mol Cell Res 1783: 994-1002.

Esteves ARF, Arduíno DM, Swerdlow RH, Oliveira CR, Cardoso SM (2008) Oxidative Stress potentiates alpha-synuclein oligomerization in PD Cybrids. Antiox. Redox Signal.

Esteves ARF, Domingues AF, Ferreira IL, Januário C, Swerdlow RH, Oliveira CR and Cardoso SM (2008) Mitochondrial dysfunction occurs in parkinson’s disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion 8,219-228.

Ferreiro E, Costa R, Marques S, Cardoso SM, Oliveira CR, Pereira C (2008) Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP106-126. J. Neurochem. 104,766-776.

Ferreiro E, Oliveira CR, Pereira CM (2008) The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol. Dis. 30,331-342.

Figueiredo C, Pais TF, Gomes JR, Chatterjee S (2008) Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2. J. Neurochem. 107, 73-85.

Gil JM, Rego AC (2008) Mechanisms of neurodegeneration in Huntington’s disease. Eur. J. Neurosci. 27, 2803-2820.

Gomes AR, Ferreira JS, Paternain AV, Lerma J, Duarte CB, Carvalho AL (2008) Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors. Mol. Cell Neurosci. 37, 323–334.

Gonçalves J, Martins T, Ferreira R, Milhazes N, Borges F, Ribeiro CF, Malva JO, Macedo TR and Silva AP (2008) Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain. Ann. N. Y. Acad. Sci. 1139:103-111.

Leal E, Aveleira CA, Castilho AF, Baptista FI, Ambrósio AF (2008) Muller cells do not influence leukocyte adhesion to retinal endothelial cells. Ocul. Immunol. Inflamm. 16:173-179.

Matos M, Augusto E, Oliveira CR, Agostinho P (2008) Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and MAP Kinase cascades. Neuroscience 156,898-910.

Rebola N, Lujan R, Cunha RA, Mulle C (2008) Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57:121-34.
Resende R, Ferreiro E, Pereira C, Oliveira CR (2008) ER stress is involved in Aβ-induced GSK-3β activation and tau phosphorylation. J. Neurosci. Res. 86,2091-2099.

Resende R, Ferreiro E, Pereira C, Oliveira CR (2008) Neurotoxic effect of oligomeric and fibrillar species of A1-42 peptide. Involvement of ER calcium release in oligomers-induced cell death. Neuroscience 155,725-737.

Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR (2008) Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic. Biol. Med. 44,2051-2057.

Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA (2008) Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats. Neurobiol. Aging 29:1597-601

Saavedra A, Baltazar G, Duarte EP (2008) Driving GDNF expression: The green and the red traffic lights. Prog. Neurobiol. 86, 186-215.

Santiago AR, Carvalho, CM, Carvalho AP, Ambrósio, AF (2008). Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons. Neurochem. Res. 33: 1501-1508.

Santiago AR, Hughes JM, Kamphuis W, Schlingemann RO and Ambrósio AF (2008) Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina. Brain Res. 1198:153-159.

Santos AR, Duarte CB (2008) Validation of internal control genes for expression studies: effects of the neurotrophin BDNF on hippocampal neurons. J. Neurosci. Res. 86, 3684-3692.

Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF (2008) A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. J. Neurosci. 28:2970-5.

Silva AM, Rodrigues RJ, Tomé AR, Cunha RA, Misler S, Rosário LM, Santos RM (2008) Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic beta cells. Pancreas 36:279-83.

Silva BA, Malva JO and Dias ACP (2008) St. John’s worth (H. perforatum) extracts and isolated compounds are effective antioxidants in several in vitro models of oxidative stress. Food Chem. 110: 611-619.

Silva B, Oliveira PJ, Dias ACP and Malva JO (2008) Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults. Neurotoxicity Res. 13: 265-279.

Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc. Natl. Acad. Sci. U.S.A. 105,19318-19323.

Xapelli S, Bernardino L, Ferreira R, Grade S, Silva AP, Salgado JR, Cavadas C, Grouzmann E, Poulsen FR, Jakobsen B, Oliveira CR, Zimmer J and Malva JO (2008) Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. Eur. J. Neurosci. 27: 2089-2102.

Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF (2008) Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Ann. Neurol. 63:338-46.



Biotechnology and Health

Alves S, Nascimento-Ferreira I, Auregan G, Hassig R, Dufour N, Brouillet E, Pedroso de Lima MC, Hantraye P, Déglon N*, Pereira de Almeida* L. (2008) Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease. *Equal Contribution. PLoS ONE  Oct 8;3(10):e3341.

Alves S, Régulier E, Nascimento-Ferreira I, Hassig R, Dufour N, Koeppen A, Carvalho AL, Simões S, Pedroso de Lima MC, Brouillet E, Colomer Gould V, Déglon N, Pereira de Almeida L (2008) Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Hum. Mol. Genet. 17: 2071-2083.

Camacho R, Alves A, Silva CG and Brito RMM (2008) On Mining Protein Unfoling Simulation Data with Inductive Logic Programming. Proceedings of the 2nd International Workshop on Practical Applications of Computational Biology and Bioinformatics (IWPACBB 2008). Advances in Soft Computing 49, 175-179. (ISBN 978-3-540-85860-7)

Cardoso ALC, Simões S, Almeida LP, Plesnila N, Lima MCP, Wagner E and Culmsee C (2008) Tf-lipoplexes for neuronal siRNA delivery in vitro and in vivo: A promising system to mediate gene silencing in the CNS. J. Control. Release 132, 113–123.

Monteiro CJP, Pereira MM, Pinto SMA, Simões AVC, Sá GFF, Arnaut LG, Formosinho SJ, Simões S and Wyatt MF (2008) Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients. Tetrahedron 64(22), 5132-5138.

Fernandes E, Jorge AM, Silva CG, and Brito RMM (2008). A Knowledge Discovery Method for the Characterization of Protein Unfolding Processes. Proceedings of the 2nd International Workshop on Practical Applications of Computational Biology and Bioinformatics (IWPACBB 2008). Advances in Soft Computing 49, 180-188. (ISBN 978-3-540-85860-7)

Faneca H, Faustino A and Lima MCP (2008) Synergistic antitumoral effect of non-viral HSV-Tk/GCV gene therapy and vinblastine in mammary adenocarcinoma cells. J. Control. Release 126, 175-184.

Ferreira L*, Karp JM, Nobre L, Langer R* (2008) New opportunities: The use of nanotechnologies to manipulate and track stem cells. Cell Stem Cell 3, 136-146. *Corresponding authors.

Ferreira L, Squier T, Park H, Choe H, Kohane DS, Langer R (2008) Human embryoid bodies containing nano- and micro-particulate delivery vehicles. Advanced Materials 20, 2285-2291.

Fuller J, Zugates G, Ferreira L, Ow H, Nguyen N, Wiesner U, Langer R (2008) Intracellular delivery of core-shell fluorescent silica nanoparticles”. Biomaterials 29, 1526- 1532.

Mahdavi A*, Ferreira L*, Sundback C, Nichol JW, Chan EP, Carter JD,Bettinger C, Patanavanich S, Chignozha L, Ben-Joseph E, Galakatos A, Pryor H, Pomerantseva I, Masiakos P, Faquin W, Zumbuehl A, Hong S, Borenstein J, Vacanti J, Langer R, Karp JM (2008) A biodegradable and biocompatible Gecko-inspired tissue adhesive". Proceedings of the National Academy of Sciences 105(7), 2307-2312. *Authors contributed equally.

Moreira JN, Santos A, Moura V, Lima MCP, Simões S (2008) Non-viral lipid-based nanoparticles towards cancer systemic gene silencing. Journal of Nanoscience and Nanotechnology May; 8:2187–2204.

Nobre RJ, Almeida LP, Martins TC. (2008) Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm. J. Clin Virol. May;42(1):13-21. Epub 2008 Mar 4.

Nunes-Correia I, Rodríguez JM, Eulálio A, Carvalho AL, Citovsky V, Simões S, Faro C, Salas ML, Pedroso de Lima MC. African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection.Vet Microbiol. 2008 Jul 27;130(1-2):47-59.

Penacho N, Filipe A, Simões S and Lima MCP (2008) Transferrin-associated lipoplexes as gene delivery systems: relevance of mode of preparation and biophysical properties. J. Membrane Biology 221, 141-152.

Pereira CS, da Costa DS, Pereira S, Nogueira Fde M, Albuquerque PM, Teixeira J, Faro C, Pissarra J (2008) Cardosins in postembryonic development of cardoon: towards an elucidation of the biological function of plant aspartic proteinases. Protoplasma 232(3-4):203-13.

Rosa M, Penacho N, Simões S, Lima MCP, Lindman B  and Miguel MG (2008) DNA precondensation with an amino acid-based cationic amphiphile. A new approach for liposome-based gene delivery. Molecular Membrane Biology 25, 23-34.

Salvador A (2008) Book review: Uri Alon ‘Introduction to Systems Biology’, Math. Biosci. 215:193-195

Santos A, Ribeiro ABS, Lima MCP, Simões S, Moreira JN (2008) Simultaneous evaluation of viability and Bcl-2 in small cell lung cancer. Cytometry – Part A, September; 73A(12):1165-1172.

Soares MIL, Lopes SMM, Cruz PF, Brito RMM, and Melo TMVDP (2008) Flash vacuum pyrolysis of 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2-vinyl-1H-pyrroles. Tetrahedron 64, 9745-9753.

Swain M, Ostropytskyy V, Silva CG, Stahl F, Riche O, Brito RMM, and Dubitzky W (2008) Grid Computing Solutions for Distributed Repositories of Protein Folding and Unfolding Simulations. Lecture Notes in Computer Science 5103, 70-79.

Trabulo S, Mano M, Faneca H, Cardoso AL, Duarte S, Henriques A, Paiva A, Gomes P, Simões S and Lima MCP (2008) S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA. J. Gene Medicine 10, 1210-1222.


Cell and Molecular Toxicology

Almeida L, Nunes T, Falcão AC, Minciu I, Magureanu SA, Butoianu N, Soares-da-Silva P (2008) Pharmacokinetics, Efficacy, and Tolerability of Eslicarbzepine Acetate in Children and Adolescents. J. Clin. Pharmacol. 48: 966-977.

Almeida L, Falcão AC, Coelho R, Albino-Teixeira A, Soares-da-Silva P (2008) The role of socio-economic conditions and personality characteristics on the willingness to volunteer for phase I studies. Pharm. Med. 22(6): 367-374.

Almeida L, Falcão AC, Vaz-da-Silva M, Coelho R, Albino-Teixeira A, Soares-da-Silva P (2008) Personality characteristics of volunteers to Phase 1 studies and likelihood of reporting adverse events. Int. J. Clin. Pharmacol. Ther. 46(7): 340-348.

Almeida L, Falcão AC, Vaz-da-Silva M, Nunes T, Santos AT, Rocha JF, Neto C, Macedo T, Fontes-Ribeiro C, Soares-da-Silva P (2008) Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Eur. J. Clin. Pharmacol. 64: 961-966.

Almeida L, Minciu I, Nunes T, Butoianu N, Falcão AC, Magureanu SA, Soares-da-Silva P (2008) Pharmacokinetics of eslicarbazepine acetate in children and adolescents with epilepsy. J. Clin. Pharmacol. 48: 966-977.

Alves E, Summavielle T, Alves CJ, Custódio JBA, Fernandes E, Bastos ML, Tavares MA, Carvalho F (2008) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addict. Biol. 14:185-93.

Alves G, Figueiredo I, Falcão AC, Castel-Branco M, Caramona MM, Soares-da-Silva P (2008) Stereoselective disposition of S- and R-Licarbazepine in the mouse. Chirality 20(6): 796-804.

Alves GL, Fortuna A, Falcão AC (2008) High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review. Trends Chromatography 4: 1-10.

Alves GL, Figueiredo IV, Castel-Branco MM, Lourenço N, Falcão AC, Caramona MM, Soares-da-Silva P (2008) Disposition of Eslicarbazepine Acetate in the Mouse after Oral Administration. Fund. Clin. Pharmacol. 22(5): 529-36.

Alves Ema, Summavielle Teresa, Alves CJ, Custódio JBA, Fernandes E, Bastos ML, Tavares MA, Carvalho F (2008) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addict. Biol. 14:185-93.

Barbosa RM, Marques CF, Santos RM, Pomerleau F, Huettl P, Gerhardt GA and Laranjinha J (2008) In vivo real time measurement of endogenous nitric oxide in anesthetized rat brain. Methods in Enzymology 441, 351-367.

Bem AF, Farina M, Portella RD, Nogueira CW, Dinis TC, Laranjinha JA, Almeida LM, Rocha JB (2008) Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro. Atherosclerosis 201, 92-100.

Brito PM, Devillard R, Nègre-Savayre A, Almeida LM, Dinis TCP, Salvayre R and Augé N (2008) Resveratrol inhibits the mTOR mitogenic signalling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis. doi:10.1016/J.Atherosclerosis.2008.11.011.

Brito PM, Simões NF, Almeida LM and Dinis TCP (2008) Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2. Apoptosis 13 1043-1053.

Cardoso S, Santos R X, Carvalho C, Correia S, Pereira GC, Pereira SS, Oliveira PJ, Santos MS, Proença T, Seiça R, Oliveira CR, Moreira P (2008) Doxorubicin Increases the Susceptibility of Brain Mitochondria to the Calcium-induced Permeability Transition and Oxidative Damage. Free Rad. Biol. Med. 45(10):1395-402.

Carvalho C, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI (2008). Metformin promotes isolated rat liver mitochondria impairment. Mol. Cell Biochem. 308(1-2):75-83.

Correia S, Carvalho C, Santos MS, Proença T, Nunes E, Duarte AI, Monteiro P, Seiça R, Oliveira CR, Moreira PI (2008) Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med Chem. 4:358-64.

Fernandes MAS, Marques RJF, Vicente JAF, Santos MS, Monteiro P, Moreno AJM, Custódio JBA (2008) Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria. Mol. Cell. Biochem. 309, 77-85.

Fernandes MAS, Pereira SPS, Jurado AS, Custódio JBA, Santos MS, Moreno AJM, Duburs G and Vicente JAF (2008) Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: relevance of the length of the alkoxyl chain in positions 3 and 5 of the DHP ring. Chemico-Biological Interactions 173: 195-204.

Fontes-Ribeiro C, Macedo T, Nunes T, Neto C, Vasconcelos T, Cerdeira R, Lima R, Rocha JF, Falcão AC, Almeida L, Soares-da-Silva P (2008) Dosage form proportionality and food-effect of the final tablet formulation of eslicarbazepine acetatein healthy volunteers. Drugs R&D. 9(6): 447-454.

Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pocock J, Laranjinha J, Heales S (2008) Glutamate Induces Release of Glutathione from Cultured Rat Astrocytes – A Possible Neuroprotective Mechanism? J. Neurochem. 105, 1144-1152.

Gago B, Nyström T, Cavaleiro C, Rocha BS, Barbosa R, Laranjinha J, Lundberg JO (2008) The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. Free Radic. Biol. Med. 45, 404-412.

Lourenço CF, Gago B, Barbosa RM, de Freitas V, Laranjinha J (2008) LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol Depletion. J. Agric. Food Chem. 56, 3798-804.

Lumini-Oliveira J, Magalhães J, Oliveira PJ, Ascensão A (2008) Beneficial Effects of Exercise on Muscle Mitochondrial Function in Diabetes. Sports Medicine 38(9):735-50.

Maia J, Almeida L, Falcão AC, Soares E, Mota F, Potgieter MA, Potgieter JH, Soares-da-Silva P (2008) Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate. Int. J. Clin. Pharmacol. Ther. 46(3): 119-130.

Mano A, Falcão AC, Godinho I, Santos J, Leitão F, Oliveira C, Caramona MM (2008) CA-125 AUC as a predictor for ovarian cancer relapse. Cancer Biomarkers 4(2): 73-81.

Monteiro JP, Oliveira PJ, Moreno AJM and Jurado AS (2008) Disruption of hepatic mitochondrial bioenergetics is not a primary mechanism for the toxicity of methoprene. Relevance for toxicological assessment. Chemosphere 72: 1347-1354.

Monteiro JP, Oliveira PJ, Jurado A, Moreno AJ (2008) Disruption of Hepatic Mitochondrial Bioenergetics and Permeability Transition by the Insectice Methoprene – Relevance for Toxicological Assessment. Chemosphere 72(9):1347-54.

Monteiro JP, Videira R, Matos MJ, Dinis A and Jurado AS (2008) Non-selective toxicological effects of the insect juvenile hormone analogue methoprene. A membrane biophysical approach. Applied Biochemistry and Biotechnology 150:243-57.

Neves MAC, Dinis TCP, Colombo G and Melo MLS (2008) Biochemical and computational insights into the anti-aromatase activity of natural catechol estrogens. J. Steroid Biochem. Mol. Biol. 110 10-17.

Nunes C, Almeida L and Laranjinha J (2008) 3,4-dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning. Neurotoxicology 29, 998-1007.

Pereira CV, Machado NG, Oliveira PJ (2008) Mechanisms of Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo (5,6-a) quinolizinium]-induced Mitochondrial Dysfunction: Interaction with the Adenine Nucleotide Translocator. Toxicol. Sci. 105(2):408-17.

Pereira CV, Moreira AC, Pereira SP, Machado NG, Carvalho FS, Sardão VA, Oliveira PJ (2008) Mitochondria: The New Comeback of an Old Biosensor for Drug Safety. Curr. Drug Safety 4(1):34-54.

Pereira GC, Oliveira PJ (2008) Pharmacological Strategies to Counteract Doxorubicin-induced Cardiotoxicity – The Role of Mitochondria. J. Theor. Exp. Pharmacol. 1 (2): 39-53.

Pupure J, Fernandes MA, Santos MS, Moreno A J, Kalvinsh I, Klusa V, Oliveira CR (2008) Mitochondria as the target for mildronates´s protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria. Cell Biochem. Function 26:620-631.

Santos RM,  Lourenço CF, Piedade AP, Andrews R, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J, Barbosa RM  (2008) A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue. Biosensors Bioelectronics 24, 704-709.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB (2008) Morphological Hallmarks of Doxorubicin Toxicity on H9c2 Moblasts: Nuclear, Mitochondrial and Cytoskeletal Targets. Cell. Biol. Toxicol. 25(3):227-43.

Sardão VA, Pereira SL, Oliveira PJ. Drug-induced Mitochondrial Dysfunction in Cardiac and Skeletal Muscle Injury. Exp. Opin. Drug Safety. 7(2):129-46.

Serafim TL, Matos JAC, Sardão VA, Pereira GC, Branco AF, Pereira SL, Parke D, Perkins EL, Moreno AJM, Holy J, Oliveira PJ (2008) Sanguinarine Cytotoxicity on Mouse Melanoma K1735-M2 Cells – Nuclear versus Mitochondrial Effects. Biochem. Pharmacol. 76: 1459-1475.

Teodoro JS, Rolo AP, Duarte FV, Simões AM, Palmeira CM (2008) Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression. Mitochondrion 8(5-6):367-76.

Varela AT, Gomes AP, Simões A, Teodoro JS, Duarte FV, Rolo AP, Palmeira CM (2008) Indirubin-3 -oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction. Toxicol. Appl. Pharmacol. 233(2):179-85.

Vaz-da-Silva M, Loureiro A, Nunes T, Lopes C, Rocha J, Costa R, Torrão L, Falcão AC, Wright L, Almeida L, Soares-da-Silva P (2008) Pharmacokinetic-pharmacodynamic interaction between Nebicapone, a novel catechol-O-methyiltransferase inhibitor, and controlled release Levodopa/Carbidopa 200 mg/50 mg. Drugs R&D. 9(6): 435-446.

Vaz-da-Silva M, Loureiro AI, Falcão AC, Nunes T, Rocha JF, Fernandes-Lopes C, Soares E, Wright L, Almeida L, Soares-da-Silva P. (2008) Effect of food on the pharmacokinetic profile of trans-resveratrol. Int. J. Clin. Pharmacol. Ther. 46 (11): 564-570.


Microbiology

Alarico S, da Costa MS, Empadinhas N (2008) Molecular and physiological role of the trehalose-hydrolyzing alpha-glucosidase from Thermus thermophilus HB27. J. Bacteriol. 190(7):2298-305.

Albuquerque L, Rainey FA, Nobre MF, da Costa MS (2008) Elioraea tepidiphila gen. nov., sp. nov., a slightly thermophilic member of the Alphaproteobacteria. Int. J. Syst. Evol. Microbiol. 58(Pt 4):773-8.

Albuquerque L, Tiago I, Taborda M, Nobre MF, Veríssimo A, da Costa MS (2008) Bacillus isabeliae sp. nov., a halophilic bacterium isolated from a sea salt evaporation pond. Int. J. Syst. Evol. Microbiol. 58(Pt 1):226-30.

Alves M, Nogueira C, de Magalhães-Santana A, Chung AP, Morais PV, da Costa MS (2008) Nosocomiicoccus ampullae gen. nov., sp. nov., isolated from the surface of bottles of saline solution used in wound cleansing. Int. J. Syst. Evol. Microbiol. 58(Pt 12):2939-44.

Antunes A, Rainey FA, Wanner G, Taborda M, Pätzold J, Nobre MF, da Costa MS, Huber R (2008) A new lineage of halophilic, wall-less, contractile bacteria from a brine-filled deep of the Red Sea. J. Bacteriol. 190(10):3580-7.

Antunes A, Taborda M, Huber R, Moissl C, Nobre MF, da Costa MS (2008) Halorhabdus tiamatea sp. nov., a non-pigmented, extremely halophilic archaeon from a deep-sea, hypersaline anoxic basin of the Red Sea, and emended description of the genus Halorhabdus. Int. J. Syst. Evol. Microbiol. 58(Pt 1):215-20.

Callegan RP, Nobre MF, McTernan PM, Battista JR, Navarro-González R, McKay CP, da Costa MS, Rainey FA (2008) Description of four novel psychrophilic, ionizing radiation-sensitive Deinococcus species from alpine environments. Int. J. Syst. Evol. Microbiol. 58(Pt 5):1252-8.

Cava F, Zafra O, da Costa MS, Berenguer J (2008) The role of the nitrate respiration element of Thermus thermophilus in the control and activity of the denitrification apparatus. Environ. Microbiol. 10(2):522-33.

Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS (2008) Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase. FEMS Microbiol. Lett. 280(2):195-202.

Empadinhas N, da Costa MS. 2008. Osmoadaptation mechanisms in prokaryotes: distribution of compatible solutes. Int Microbiol. 11(3):151-61.

Empadinhas N, da Costa MS (2008) To be or not to be a compatible solute: bioversatility of mannosylglycerate and glucosylglycerate. Syst. Appl. Microbiol. 31(3):159-68.

Hipolito E, Faria E, Alves AF, de Hoog GS, Anjos J, Gonçalves T, Morais PV, Estevão H (2008) Alternaria infectoria brain abscess in a child with chronic granulomatous disease. Eur. J. Clin Microbiol Infect. Dis. 28: 377-380.

Nobre A, Alarico S, Fernandes C, Empadinhas N, da Costa MS (2008) A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: properties of a rare actinobacterial TreT. J. Bacteriol. 190(24):7939-46.

Paulo C, Mourão C, Veiga PM, Marques JM, Rocha G, Alves AF; Querol A, Meliço-Silvestre AA, Gonçalves I, Flores, ClementeC, Gonçalves T (2008) Retrospective analysis of clinical yeast isolates in a hospital in the centre of Portugal: spectrum and revision of the identification procedures. Med. Mycol. DOI: 10.1080/13693780802709081.

Pereira PJ, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S (2008) Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis. PLoS ONE 3(11):e3748.

Sá-Moura B, Albuquerque L, Empadinhas N, da Costa MS, Pereira PJ, Macedo-Ribeiro S (2008) Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase fromRubrobacter xylanophilus. Acta Crystallogr. Sec.t F. Struct. Biol. Cryst. Commun. 1;64(Pt 8):760-3.


Biophysics and Biomedical NMR

Alves T, Nunes P, Palmeira C, Jones JG and Carvalho R (2008) Estimating gluconeogenesis by NMR isotopomer distribution analysis (NMR-IDA) of [13C]bicarbonate and [1-13C]lactate. NMR in Biomedicine 21, 337-344.

Ananias D, Ferdov S, Paz FAA, Sá Ferreira RA, Ferreira A, Geraldes CFGC, Carlos LD, Lin Z, Rocha J (2008) Multifunctional Layered Lanthanide Silicate Nanoparticles Chem. Materials 20, 205-212.

Burrows HD, Fonseca SM, Melo JSS, Ramos ML, Sobral AJFN, Kogej K, Azenha ME (2008) Luminescense from cerium (III) acetate complexes in aqueous solution: considerations on the nature of carboxylate binding to trivalent lanthanides. New J. Chem. 32, 1531-1535.

Burrows HD, Knaapila M, Monkman AP, Tapia MJ, Fonseca SM, Ramos ML, Pyckhout-Hintzen W, Pradhan S, Scherf U (2008) Structural studies on cationic poly{9,9-bis[6-(N,N,N-trimethylammonium) alkyl]fluorene-co-1,4-phenylene} iodides in aqueous solutions in the presence of the nonionic surfactant pentaethyleneglycol monododecyl ether (C12E5). J. Phys. Condensed Matter. 20, 104210-104216.

Caravan P, Geraldes CFGC, Greenfield MT, Kiefer GE, Lin M, McMillan K, Prata MIM, Santos AC, Sherry AD, Sun X, Wang J, Woods M, Zhang S and Zhao P (2008) The effect of charge on the biodistribution and CEST properties of lanthanide(III) DOTA-tetraamide derivatives. Investig. Radiol. 43, 861-870.

Costa D, Ramos ML, Burrows HD, Tapia MJ, Miguel MG. (2008) Using lanthanides as probes for polyelectrolyte-metal ion interactions and hydration changes on binding of trivalent cations to nucleotides and nucleic acids. Chem. Phys. 352, 241-248.

*Delgado TC, Barosa C, Castro MMCA, Geraldes CFGC, Bastos M, Baptista C, Fagulha A, Barros L, Mota A, Carvalheiro M, Jones JG, Merritt M (2008) Sources of Hepatic Glucose Production By 2H2O Ingestion and Bayesian Analysis of 2H Glucuronide Enrichment. Magn. Reson. Med. 60, 517-523.

Figueiras A, Sarraguça JMG, Pais AACC, Veiga FJ, Carvalho RA (2008) New insight into the discrimination between omeprazole enantiomers by cyclodextrins in aqueous solution. J. Incl. Phenom. & Macrocyclic Chem. 62, 345-351.

Jones JG, Garcia P, Barosa C, Delgado TC, Caldeira MM and Diogo L (2008) Quantification of hepatic transaldolase exchange activity and its effects on tracer measurements of indirect pathway flux in humans. Magn. Res. Med. 59, 423-429.

Justino LLG, Ramos ML, Nogueira F, Sobral AJFN, Geraldes CFGC, Kaupp M, Burrows HD, Fiolhais C, Gil VMS (2008) Oxoperoxo vanadium(V) complexes of L-lactic acid: density functional theory study of structure and NMR chemical shifts. Inorg. Chem. 47, 7317-7326.

Knaapila M, Almásy L, Garamus VM, Ramos ML, Justino LLG, Torkkeli M, Dias FB, Scherf U, Burrows HD, Monkman AP (2008) An effect of side chain length on the solution structure of poly(9,9-dialkylfluorene)s in toluene. Polymer 49, 2033-2038.

Marques AT, Silva JA, Silva MR, Matos Beja A, Justino LLG, Sobral AJFN (2008) X-Ray diffraction and DFT studies of 2-methoxy-5-phenylaniline. J. Chem. Crystallogr. 38: 295-299.

Nunes PN, Carvalho EL and Jones JG (2008) Elimination of glucose contamination from adipocyte glycogen extracts. Carbohydrate Research 343, 1086-1089.

Pereira GA, Norek M, Peters JA, Ananias D, Rocha J, Geraldes CFGC (2008) NMR Transversal Relaxivity of Aqueous Suspensions of Particles of Ln3+ -Based Zeolite Type Materials. Dalton Trans. 2241-2247. (chosen for issue cover)

Rosário LM, Barbosa RM, Antunes CM, Baldeiras IE, Silva AM, Tomé AR, Santos RM (2008) Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in absence of functional KATP channels. Endocr J. 55: 639-650.

Sobral AJFN, Justino LLG, Santos ACC, Silva JA, Arranja CT, Silva MR, Beja AM (2008) Synthesis and Structural Characterization of a New Self-Assembled Disulphide Linked meso-Tetrakis-Porphyrin Macromolecular Array. J. Porphyr. Phthalocya. 12, 845 – 848.

Sousa PL, Livramento JB, Helm L, Merbach AE, Même W, Doan BT, Beloeil JC, Prata MIM, Santos AC, Geraldes CFGC, Tóth E (2008) In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications. Contrast Media Mol. Imaging 3, 78-85.

Torres S, Prata MIM, Santos AC, André JP, Martins JA, Helm L, Tóth E, García-Martín ML, Rodrigues TB, López-Larrubia P, Cerdán S, Geraldes CFGC (2008) Gd(III)-EPTPAC_16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and /in vivo/ animal imaging studies. NMR Biomed. 21, 322–336.

Urbano AM, Rodrigues CFD, Alpoim MC (2008) Hexavalent chromium exposure, genomic instability and lung cancer. Gene Therapy Mol. Biol. 12, 219-238.

Woitiski CB, Carvalho RA, Ribeiro AJ, Neufeld RJ, Veiga FJ (2008) Understanding of particle uptake and translocation to improve strategies for oral insulin delivery. BioDrugs 22, 223-237.


Cell and Development Biology

Amaral S, Mota P, Rodrigues AS, Martins L, Oliveira PJ and Ramalho-Santos J (2008) Testicular aging involves mitochondrial dysfunction and UCP2-mediated proton leak. FEBS Letters 582:4191-4196.

Amaral S, Oliveira PJ and Ramalho-Santos J (2008) Diabetes and the impairment of Reproductive Function: Possible role of mitochondria and reactive oxygen species. Current Diabetes Reviews 4:46-54.

Karagiannides I, Torres D, Tseng Y-H, Bowe C, Carvalho E, Espinoza D, Pothoulakis C and Kokkotou E (2008) Substance P as a novel anti-obesity target. Gastroenterology 134(3):747-55.

Mobasheri A, Bondy CA, Moley K, Mendes AF, Rosa SC, Richardson S, Hoyland JA, Barrett-Jolley R, Shakibaei M (2008) Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytokines. Adv. Anat. Embryol. Cell Biol. 200:1-84.

Morte MI, Rodrigues AM, Soares D, Rodrigues AS, Gamboa S and Ramalho-Santos J (2008)The quantification of lipid and protein oxidation in stallion spermatozoa and seminal plasma: Seasonal distinctions and correlations with DNA strand breaks, classical seminal parameters and stallion fertility. Animal Reproduction Science 106:36-47.

Neves BM, Cruz MT, Francisco V, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC (2008) Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line. Toxicol. Lett. 177: 74-82.

Neves BM, Francisco V, Cruz MT, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC (2008) Modulation of CXCR4 by sensitizers and irritants in dendritic cells. Contact Dermatitis 58: 10-11.
Nobre RJ, Almeida LP, Martins TC. Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm. J. Clin. Virol. 2008, 42: 13-21.

Prazeres HJ, Rodrigues F, Naidenov P, Figueiredo P, Soares P, Lacerda M, Campos B, Martins TC (2008) Loss of heterozygosity at 19p13.2 and 2q21 in tumours from familial clusters of non-medullary thyroid carcinoma. Familial Cancer 7: 141-9.

Rodrigues AS, Sarmento-Ribeiro AB, Ramos F et al (2008) Development of an analytical methodology for simultaneous determination of vincristine and doxorubicin in pharmaceutical preparations for oncology by HPLC-UV. J. Chromatographic Sci. 47: 1-5.

Rosa SC, Judas F, Lopes MC, Mendes AF (2008) Nitric oxide synthase isoforms and NF-κB activity in normal and osteoarthritic human chondrocytes: Regulation by inducible nitric oxide. Nitric Oxide 19: 276-283.

Sánchez-Partida G, Simerly CR and Ramalho-Santos J (2008) Freeze-Dried primate sperm retains early development potency after Intracytoplasmic Sperm Injection (ICSI) L. Fertility and Sterility 89:742-745.

Tavares AC, Gonçalves MJ, Cavaleiro C, Cruz MT, Lopes MC, Canhoto J, Salgueiro L (2008) Chemical composition, antifungal activity and cytotoxicity of the essential oil of Daucus carota subsp. Halophilus. J. Ethnopharmacol.  119: 129-134.

*Vieira O*, Hartmann D, Cardoso C, Oberdoerfer D, Baptista M, Santos M, Almeida L, Ramalho-Santos J and Vaz WL (2008) Surfactants as microbicides and contraceptive agents: A systematic in vitro study. PLoS ONE 6; 3(8):e2913. *Corresponding author.