Agostinho P, and Oliveira CR. (2007) Neuroinflammation and mitochondrial dysfunction in Alzheimer´s and Prion´s diseases. In: "Interaction Between neurons and glia in aging and disease", Chapter 14, pp 309-332. Malva JO, Rego AC, Cunha RA. Oliveira CR. eds. Springer Publishers, New York, USA (chapter in book)

Alvaro AR, Rosmaninho-Salgado J, Santiago AR, Martins J, Aveleira C, Santos PF, Pereira T, Gouveia D, Carvalho AL, Grouzmann E, Ambrósio AF, Cavadas C. (2007) NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells. Neurochem Int. 50: 757-63.

Araújo IM, Carreira BP, Pereira T, Santos PF, Soulet D, Inácio A, Bahr BA, Carvalho AP, Ambrósio AF, Carvalho CM. (2007) Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons. Cell Death Differ. 14:1635-1646.

Borycz J, Pereira MF, Melani A, Rodrigues RJ, Köfalvi A, Panlilio L, Pedata F, Goldberg SR, Cunha RA, Ferré S. (2007) Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments. J. Neurochem. 101:355-363.

Caldeira MV, Melo CV, Pereira DB, Carvalho R, Correia SS, Backos DS, Carvalho AL, Esteban JA, Duarte CB. (2007) Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons. J Biol Chem. 282: 12619-12628.

Caldeira MV, Melo CV, Pereira DB, Carvalho RF, Carvalho AL, Duarte CB. (2007) BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons. Mol Cell Neurosci 35: 208-219.

Caldeira MV, Melo CV, Pereira DB, Carvalho R, Correia SS, Backos DS, Carvalho AL, Esteban JA, Duarte CB. (2007). BDNF regulates the expression and the synaptic delivery of AMPA receptor subunits in hippocampal neurons. J Biol Chem. 282:12619-12628.

Casadeus G, Moreira PI, Nunomura A, Siedlak SL, Bligh-Glover W, Balraj E, Petot G, Smith MA, Perry G. (2007)  Indices of metabolic dysfunction and oxidative stress. Neurochem. Res. 32:717-722 (Review)

Castellani RJ, Moreira PI, Liu G, Dobson J, Perry G, Smith MA, Zhu X. (2007) Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease. Neurochem. Res. 32:1640-1645 (Review)

Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA. (2007) Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Rev. Neurother. 7:473-485 (Review)

Cavadas C, Waeber B, Pedrazzini T, Grand D, Aubert JF, Buclin T, Grouzmann E. (2007). NPY Y1 receptor is not involved in the hemodynamic response to an acute cold pressor test in mice. Peptides 28: 315-9.

Cruz MT, Neves BM, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC. (2007) Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: role of different immunosuppressive drugs. Immunopharmacol Immunotoxicol 29:225-41.

Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR. (2007) Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons. J. Neurochem. 101:543-554.

Cunha-Oliveira T, Rego AC, Macedo T, Oliveira CR. (2007) Changes in the activity of antioxidant enzymes in PC12 cells chronically exposed to psychostimulants. Proceedings of the European Meeting of the Society for Free Radical Research, Medimond International Proceedings, HX10C0103, pg. 21-24.

Cunha RA, Chen JF, Sitkovsky MV. (2007) Opposite modulation of peripheral inflammation and neuroinflammation by adenosine A2A receptors. In: Interaction Between Neurons and Glia in Aging and Disease, eds. JO Malva, AC Rego, RA Cunha, CR Oliveira, pp.53-79, Springer-Verlag, Berlim.

Cunha RA. (2007) ‘Regulação Bioquímica’. In: ‘Bioquímica – Organização Molecular da Vida’, eds. A Quintas, AP Freire, MJ Halpern, pp.601-618, Lidel, Lisboa.

Dall’Igna OP, Fett P, Gomes MW, Souza DO, Cunha RA, Lara DR. (2007) Caffeine and adenosine A2A receptor antagonists prevent -amyloid (25-35)-induced cognitive deficits in mice. Exp. Neurol. 203:241-245.

Domingues A, Almeida S, da Cruz e Silva EF, Oliveira CR, Rego AC. (2007) Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. Neurochem. Int. 50:872-880.

Duarte AI, Proença T, Oliveira CR, Santos MS, Rego AC. (2007) Insulin neuroprotection against oxidative stress involves increased antioxidant defenses and glucose metabolism. Proceedings of the European Meeting of the Society for Free Radical Research, Medimond International Proceedings, HX10C0106, pg. 41-44.

Duarte AS, Rosa N, Duarte EP, Pires E, Barros MT. (2007) Cardosins: a new and efficient plant enzymatic tool to dissociate neuronal cells for the establishment of cell cultures. Biotechnol. Bioeng. 97: 991-996.

Duarte EP, Saavedra A, Baltazar G. (2007) GDNF: a key player in neuron-glia crosstalk and survival of nigrostriatal dopaminergic neurons. In Interaction between neurons and glia in aging and disease. Eds. Malva J.O., Rego A.C., Cunha R.A. & Oliveira C.R., Springer-Verlag, Berlin. pp 173-192.

Duarte JMN, Nogueira C, Mackie K, Oliveira CR, Cunha RA, Köfalvi A. (2007) Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats. Exp. Neurol. 204:479-484.

Duarte JMN, Oses JP, Rodrigues RJ, Cunha RA. (2007) Modification of purinergic signalling in the hippocampus of streptozotocin-induced diabetic rats. Neuroscience 149:382-391.

Duarte JMN, Cunha RA, Carvalho RA. (2007) Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by NMR spectroscopy. Neuroscience 144:1305-1313.

Ferré S, Ciruela F, Quiroz C, Luján R, Popoli P, Cunha RA, Agnati LF, Fuxe K, Woods AS, Lluis C, Franco R. (2007) Adenosine receptor heteromers and their integrative role in striatal function. Sci. World J. 7(S2):74-85.

Ferreiro E, Eufrásio A, Pereira C, Oliveira CR, Rego AC. (2007) Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells. J. Alzheimers Dis. 12:223-228.

Ferreiro E, Costa R, Marques S, Oliveira CR, Pereira C. (2007) Role of endoplasmic reticulum-mediated apoptotic pathway in A Toxicity. Cognitive Sci. 2:1-26 (Review)

Ferro A, Carvalho AL, Teixeira-Castro A, Almeida C, Tomé RJ, Cortes L, Rodrigues AJ, Logarinho E, Sequeiros J, Macedo-Ribeiro S, Maciel P. (2007) NEDD8: a new ataxin-3 interactor. Biochim Biophys Acta. 1773: 1619-27.

Gomes AR, Correia SS, Esteban JA. Duarte CB, and Carvalho AL. (2007) PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression. Traffic 8: 259-269.

Köfalvi A, Pereira MF, Rebola N, Rodrigues RJ, Oliveira CR, Cunha RA. (2007) Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. Br. J. Pharmacol. 151:551-563.

Leal EC, Manivannan A, Hosoya K-I, Terasaki T, Cunha-Vaz J, Ambrósio AF, Forrester JV. (2007) Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 48:5257-5265.

Liu Q, Xie F, Rolston R, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. (2007)  Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Rev. Med. Chem. 7:171-180 (Review)

Lopes JP, Oliveira CR, Agostinho P. (2007) Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimers disease and prion-related encephalopathies. Cell. Mol. Neurobiol. 27, 943-957.

Macedo-Ribeiro S, de Almeida LP, Carvalho AL, Rego AC. (2007) Polyglutamine expansion diseases – the case of Machado-Joseph disease. In: ‘Interaction Between Neurons and Glia in Aging and Disease’ (Malva J; Rego AC; Cunha R; Oliveira C, Eds.), Springer, Chapter 18, pp. 391-426.

Manadas BJ, Melo CV, Gomes JR, Duarte CB. (2007) Neurotrophin signalling and cell survival. In: Interaction between neurons and glia in aging and disease. Eds. Malva J.O., Rego A.C., Cunha R.A., Oliveira C.R. Springer-Verlag, Berlin. pp. 137-172.

Melo JB, Agostinho P, Oliveira CR. (2007) Prion protein aggregation and neurotoxicity in cortical neurons. Ann N Y Acad Sci. 1096:220-229.

Montezinho LP, Mørk A, Duarte CB., Penschuck S, Geraldes CFGC, and Castro MCA. (2007) Effects of mood-stabilizers on the inhibition of adenylate cyclase via dopamine D2-like receptors. Bipolar Disorders 9: 290-297.

Moreira PI, Harris PLR, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. (2007) Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J. Alzheimer Dis. 12:195-206.

Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. (2007) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J. Neuropathol. Exp. Neurol. 66:525-532.

Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI. Aliev G, Smith MA, Zhu X, Perry G. (2007) Increased Autophagic Degradation of Mitochondria in Alzheimer Disease. Autophagy 3:614-615 (Review)

Moreira PI, Santos MS, Oliveira CR. (2007) Alzheimer disease: a lesson from mitochondrial dysfunction. Antioxid. Redox Signal. 9:1621-1630 (Review).

Moreira PI, Santos MS, Seiça R, Oliveira CR. (2007) Brain mitochondrial dysfunction as a link between Alzheimers disease and diabetes. J. Neurol. Sci. 257:206-214 (Review).

Oliveira JM, Jekabsons MB, Chen S, Lin A. Rego AC, Gonçalves J, Ellerby LM, Nicholls DG. (2007) Mitochondrial dysfunction in Huntington’s disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. J. Neurochem. 101:241-249.

Perfeito R, Pereira J, Oliveira CR, Bettencourt-Relvas J, Rego AC. (2007) Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes. Free Radical Res. 41:444-451.

Pinheiro P, Perrais D, Coussen F, Barhanin J, Bettler B, Mann JR, Malva JO, Heinemann SF, Mulle C. (2007) GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. USA 104:12181-12186.

Rebola N, Sachidhanandam S, Perrais D, Cunha RA, Mulle C. (2007) Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses. J. Neurosci. 27:3987-3993.

Rego AC, Cardoso SM, Oliveira CR. (2007) Molecular pathways of mitochondrial dysfunction in neurodegeneration: the paradigms of Parkinson’s and Huntington’s diseases. In: "Interaction Between neurons and glia in aging and disease", Chapter 9, pp 193-220. Malva J.O., Rego A.C., Cunha R.A. Oliveira C.R. eds. Springer Publishers, New York, USA (chapter in book)

Rego AC, Oliveira CR (2007) Neurodegeneration and inflammation in age related diseases. In: ‘Interaction Between Neurons and Glia in Aging and Disease’ (Malva J, Rego AC, Cunha R, Oliveira C, Eds), Springer, Section 3, pp. 269-270.

Resende R, Pereira C, Agostinho P, Vieira AP, Malva JO, Oliveira CR. (2007) Susceptibility of hippocampal neurons to A peptide toxicity is associated with perturbation of Ca2+ homeostasis Brain Res. 1143:11-21.

Rosmaninho-Salgado J, Álvaro AR, Grouzmann E, Duarte EP, Cavadas C. (2007) Neuropeptide Y regulates catecholamine release evoked by interleukin-1β in mouse chromaffin cells. Peptides 28: 310-314.

Rosmaninho-Salgado J, Araújo IM, Alvaro AR, Duarte EP, Cavadas C. (2007) Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells. J. Neurochem. 103: 896-903.

Rosmaninho-Salgado J, Alvaro AR, Grouzmann E, Duarte EP, Cavadas C. (2007) Neuropeptide Y regulates catecholamine release evoked by interleukin-1 in mouse chromaffin cells. Peptides 28:310-314.

Saavedra A, Baltazar G, Duarte EP. (2007) Interleukin-1 mediates GDNF up-regulation upon dopaminergic injury in ventral midbrain cell cultures. Neurob. Dis. 25: 92-104.

Santiago AR, Cristóvão AJ, Santos PF, Carvalho CM, Ambrósio AF. (2007) High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol. Dis. 25:464-472.

Santos SC, Vala I, Miguel C, Barata JT, Garção P, Agostinho P, Mendes M, Coelho AV, Calado A, Oliveira CR, e Silva JM, Saldanha C. (2007)  Expression and subcellular localization of a novel nuclear acetylcholinesterase protein. J. Biol. Chem. 282:25597-25603.

Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferré S. (2007) Adenosine A2A receptors and basal ganglia physiology. Progr. Neurobiol. 83:277-292.

Silva AP, Lourenço J, Xapelli S, Ferreira R, Kristiansen H, Woldbye DP, Oliveira CR, Malva JO. (2007) Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus. FASEB J 21:671-681.

Silva BA, Oliveira PJ, Dia ACP, Malva JO. (2007) Mitochondria as target for neuronal protection against excitotoxicity: a role for phenolic compounds? Cent Nerv Syst Agents Med Chem 7:205-222.

Silva CG, Porciúncula LO, Canas PM, Oliveira CR, Cunha RA. (2007) Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiol. Dis. 27:182-189.

Simões PF, Silva AP, Pereira FC, Marques E, Grade S, Milhazes N, Borges F, Ribeiro CF, Macedo TR. (2007) Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory. Neuroscience 150:433-41.

Xapelli S, Silva AP, Ferreira R, Malva JO. (2007) Neuropeptide Y can rescue neurons from cell death following the application of an excitotoxic insult with kainate in rat organotypic hippocampal slice cultures. Peptides 28:288-294.

Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadeus G, Harris PL, Siedlak SL, Perry G. (2007) Vascular oxidative stress in Alzheimer disease. J. Neurol. Sci. 257:240-246 (Review)



Biotechnology and Health


Andrade, X., Botti, S., Marques, M.A.L., and Rubio, A. (2007). A time-dependent density functional theory scheme for
efficient calculations of dynamic (hyper)polarizabilities. J. Chem. Phys. 126, 184106.

Bertin S, Neves S, Gavelli A, Baqué P, Brossete N, Rossi B, Simões S, Pedroso de Lima MC, Pierrefite-Carle V. (2007) Cellular and molecular events associated with the antitumor response induced by the cytosine deaminase/5-fluorocytosine suicide gene therapy system in a rat liver metastasis model. Can. Gene Ther. 14:858-866.

Bertin S, Neves S, Pedroso de Lima M, Pierrefite-Carle V. (2007) Naked DNA and lipoplexes applications in cancer gene therapy. Bull. Cancer 94:243-252.

Cardoso ALC, Simões S, Almeida LP, Pelisek J, Culmsee C, Wagner E, Pedroso de Lima MC. (2007) siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing. J. Gene Med. 9:170-183.

Duzgunes N, Simões S, Lopez-Mesas M, Pedroso de Lima MC. (2007) Intracellular delivery of therapeutic oligonucleotides in pH-sensitive and cationic liposomes. In: Liposome Technology Vol. 3, Chapter 14 (G. Gregoriadis Ed.), Marcel Dekker, Inc., New York, pp. 253-275.

Eulálio A, Nunes-Correia I, Salas J, Salas ML, Simões S, Pedroso de Lima MC. (2007) The structural protein p37 of African swine fever virus is localized in the nucleus at early times of viral infection. Vírus Res. 130:18-27.

Faneca H, Cabrita AS, Simões S, Pedroso de Lima MC. (2007) Evaluation of the antitumoral effect mediated by IL-12 and HSV-tk genes when delivered by a novel lipid-based system. Biochim. Biophys. Acta 1768:1093-1102.

Ferreira LS*, Zumbuehl A*, Kuhn D, Astashkina A, Long L, Yeo Y, Iaconis T, Ghannoum M, Fink GR, Langer R, Kohane DS. (2007) “Antifungal hydrogels”. Proceedings of the National Academy of Sciences, 104, 12994-12998. *Authors contributed equally.

Ferreira L, Gerecht-Nir S, Shieh HF, Watson N, Rupnick M, Dallabrida SM Vunjak-Novakovic G, Robert Langer R. (2007) “Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle-like cells and form vascular networks in vivo”. Circulation Research, 101, 286-294.

Ferreira L, Gerecht S, Fuller J, Shieh HF, Vunjak-Novakovic G, Langer R. (2007) “Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells”. Biomaterials, 28(17), 2706-2717.

Ferreira* L, Khademhosseini* A, Karp* JM, Gerecht-Nir* S, Vunjak-Novakovic G, Langer R. (2007) “Embryonic stem cells as a cell source for tissue engineering”. In: “Principles of Tissue Engineering- 3rd edition”. Editors: Lanza, R., Langer, R., Vacanti, J.P. Elsevier/Academic Press. (*Authors contributed equally).

Ferreira, P.G., Silva, C.G., Brito, R.M.M., and Azevedo, P.J. (2007). A closer look on protein unfolding simulations
through hierarchical clustering. Proceedings of the 2007 IEEE Symposium on Computational Intelligence in Bioinformatics and
Computational Biology (CIBCB07), pp. 461-468.

Gerecht-Nir S, Burdick JA, Ferreira LS, Langer R, Vunjak-Novakovic G. (2007) “Propagation of undifferentiated human embryonic stem cells in 3-dimentional hyaluronic acid networks”. Proceedings of the National Academy of Sciences, 104(27), 11298-11303.

Hansen D, Macedo-Ribeiro S, Veríssimo P, Yoo Im S, Sampaio UM, and Oliva ML. (2007) Crystal structure of a novel cysteinless plant kunitz-type protease inhibitor. Biochem. Biophys Res Commun. 360: 735-40.

Karp JM, Mahdavi A, Ferreira LS, Khademhosseini A, Langer R.  (2007) “In vitro differentiation of human embryonic stem cells along osteogenic pathways”. In: “Human Embryonic Stem Cells: A Practical Handbook”, edited by: Sullivan S, Cowan C, Eggan K. John Wiley & Sons, Ltd.

Luo, Y, Ferreira, L, Langer R. (2007) “Three-dimensional scaffolds”. In: “Principles of Tissue Engineering- 3rd edition”. Editors: Lanza, R., Langer, R., Vacanti, J.P. Elsevier/Academic Press.

Macedo-Ribeiro S, Pereira de Almeida L, Carvalho A, Rego A (2007) Polyglutamine expansion diseases – the case of Machado-Joseph disease. In: Interactions Between Neurons and Glia in Aging and Disease (Malva J, Rego A, Oliveira C, Cunha R, eds): Springer.

Mano M, Henriques A, Paiva A, Prieto M, Gavilanes F, Simões S, Pedroso de Lima MC. (2007) Interaction of S413-PV cell penetrating peptide with model membranes: Relevance to peptide translocation across biological membranes. J. Peptide Sci.13:301-313.
Nijst C, Joost J, Karp JM, Ferreira L, Zumbuehl A, Bettinger C, Langer R. “Development of Multifunctional Photocurable Degradable Elastomers”. Biomacromolecules 2007, 8, 3067-3073.

Pimentel C, Van der Straeten D, Pires E, Faro C, and Rodrigues-Pousada C. (2007) Characterization and expression analysis of the aspartic protease family of Cynara cardunculus L.  FEBS J. 274: 2523-39.

Simões I, Faro MR, Bur D, and Faro C. (2007) Characterization of recombinant CDR1, an Arabidopsis aspartic protease involved in disease resistance J. Biol. Chem. 282: 31358-65.


Cell and Molecular Toxicology


Almeida B, Buttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osorio NS, Kollau A, Mayer B, Leao C, Laranjinha J, Rodrigues F, Madeo F, Ludovico P. (2007) NO-mediated apoptosis in yeast. J. Cell. Sci. 120(Pt 18) 3279-3288.

Alves G, Figueiredo I, Castel-Branco M, Loureiro A, Fortuna A, Falcão AC, and Caramona MM. (2007) Enantioselective HPLC-UV method for eslicarbazepine acetate (BIA 2-093) and its metabolites determination in human plasma. Biomed. Chromatogr. 21(11): 1127-1134

Alves G, Figueiredo I, Castel-Branco M, Loureiro A, Falcão AC, and Caramona MM. (2007) Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection. Anal. Chim. Acta. 596(1): 132-140.

Ascensão A, Ferreira R, Oliveira PJ, Magalhães J. (2007) Effects of Endurance Training and Acute Doxorubicin Treatment on Rat Heart Mitochondrial Alterations Induced by in vitro Anoxia-reoxygenation, Cardiovasc. Toxicol. 6(3-4):159-72.

Correia HS, Batista MT, Dinis TCP. (2007) The activity of an extract and fraction of Agrimonia eupatoria L. against reactive species. Biofactors 29:91-104.

Falcão AC, Maia J, Almeida L, Mazur D, Gellert M, Soares-da-Silva P. (2007) Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker. Biopharm. Drug Dispos. 28:249-256.

Gago G, Lundberg JO, Barbosa RM, Laranjinha J. (2007) Red wine-dependent reduction of nitrite to nitric oxide in the stomach. Free Rad. Biol. Med. 43:1233-1242.

Laranjinha J, Ledo A. (2007) Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria. Frontiers in Bioscience, 12:1094-1106.

Magalhães J, Ferreira R, Neuparth MJ, Oliveira PJ, Marques F, Ascensão A. (2007) Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle. Clin Sci (Lond). Dec;113(12):459-66.

Moreira PI, Custódio JB, Nunes E, Moreno A, Seiça R, Oliveira CR, Santos MS (2007). Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats. Toxicol Appl Pharmacol. 221(1):102-10.

Moreno AJ, Oliveira PJ, Nova CD, Alvaro AR, Moreira RA, Santos SM, Macedo T. (2007) Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in Wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization. J Biochem Mol Toxicol.; 21(2):53-61.

Moreno AJ, Serafim TL, Oliveira PJ, Madeira VM. (2007) Inhibition of mitochondrial bioenergetics by carbaryl is only evident for higher concentrations -- Relevance for carbaryl toxicity mechanisms. Chemosphere;66(3):404-11.

Neves MAC, Dinis TCP, Colombo G, Sá e Melo, M.L. (2007). Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols. Chem. Med. Chem. 2:1750-1762.

Nunes E, Peixoto F, Louro T, Sena CM, Santos MS, Matafome P, Moreira PI, Seiça R. (2007) Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets. Acta Diabetol; 44:121-130.

Osório NS, Carvalho A, Almeida AJ, Padilla-Lopez S, Leao C, Laranjinha J, Ludovico P, Pearce DA, Rodrigues F. (2007) Nitric oxide signaling is disrupted in the yeast model for Batten disease. Mol. Biol. Cell. 18:2755-2767.

Palmeira CM, Rolo AP, Berthiaume J, Bjork JA, Wallace KB. Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis. Toxicol Appl Pharmacol. 225(2):214-20.

Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ. (2007) Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. J Pharmacol Exp Ther.; 323(2):636-49.

Ribeiro L, Falcão AC, Patrício JAB, Ferreira DC, and Veiga FJB. (2007) Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimise the oral bioavailability of vinpocetine. J. Pharmacol. Sci. 96(8): 2018-2028.
Rocha MJ, Almeida AM, Falcão AC, and Caramona MM. (2007) Performance of gentamicin population kinetic parameters in Portuguese neonates. Pharm. World Sci. 29(3): 104-108.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. (2007) Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death. BMC Cell Biol. Mar 16;8:11.

Silva BA, Oliveira PJ, Dias AC, Malva JO.(2007) Mitochondria as Targets for Neuronal Protection Against Excitotoxicity: A Role for Phenolic Compounds? Cur. Nerv. Syst. Agents Med. Chem. 7 (3): 205-222.


Microbiology


Alarico S, Empadinhas N, Mingote A, Simões C, Santos MS, da Costa MS. (2007) Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1. Extremophiles 11:833-840.

Albuquerque L, Tiago I, Rainey FA, Taborda M, Nobre MF, Veríssimo A, da Costa MS. (2007) Salirhabdus euzebyi gen. nov., sp. nov., a Gram-positive, halotolerant bacterium isolated from a sea salt evaporation pond. Int. J. Syst. Evol. Microbiol. 57:1566-1571.

Antunes A, França L, Rainey FA, Huber R, Nobre MF, Edwards KJ, da Costa MS. (2007) Marinobacter salsuginis sp. nov., isolated from the brine-seawater interface of the Shaban Deep, Red Sea. Int. J. Syst. Evol. Microbiol. 57:1035-1040.

Bae HS, Rash BA, Rainey FA, Nobre MF, Tiago I, da Costa MS, Moe WM. (2007) Description of Azospira restricta sp. nov., a nitrogen-fixing bacterium isolated from groundwater. Int. J. Syst. Evol. Microbiol. 57:1521-1526.

Costa J, Empadinhas N, da Costa MS. (2007) Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina. J. Bacteriol. 189:1648-1654.

Empadinhas N, Mendes V, Simões C, Santos MS, Mingote A, Lamosa P, Santos H, da Costa MS. (2007) Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile. Extremophiles 11:667-673.

Egorova K, Grudieva T, Morinez C, Kube J, Santos H, da Costa MS, Antranikian G. (2007) High yield of mannosylglycerate production by upshock fermentation and bacterial milking of trehalose-deficient mutant Thermus thermophilus RQ-1. Appl. Microbiol. Biotechnol. 75:1039-1045.

Fernandes C, Empadinhas N, da Costa MS. (2007) Single-step pathway for synthesis of glucosylglycerate in Persephonella marina. J. Bacteriol. 189:4014-4019.

Rainey FA, Ferreira M, Nobre MF, Ray K, Bagaley D, Earl AM, Battista JR, Gómez-Silva B, McKay CP, da Costa MS. (2007) Deinococcus peraridilitoris sp. nov., isolated from a coastal desert. Int. J. Syst. Evol. Microbiol. 57:1408-1412.

Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H. (2007) Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles. J. Bacteriol. 189:5405-5412.


Biophysics and Biomedical NMR


Cauli O, López-Larrubia P, Rodrigues TB, Cerdán S, Felipo V. (2007) Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors. J Neurochem. 103: 1334-1343.

Costa Pessoa J, Cavaco I, Correia I, Tomaz I, Adão P, Vale I, Ribeiro I, Castro MMCA, Geraldes CFGC. (2007) Vanadium Schiff base complexes: chemistry, properties and concerns about possible therapeutic applications. In: Vanadium the Versatile Metal, ACS Symposium Series, K.  Kustin, J.C. Pessoa, D.C. Crans, Eds., ACS Symposium Series 974, Chapter 24, American Chemical Society, Washington, DC, p. 340- 351.

Costa VM, Silva R, Ferreira LM, Branco PS, Carvalho F, Bastos ML, Carvalho RA, Carvalho M, Remião F. (2007) Oxidation process of adrenaline in freshly isolated cardiomyocites: formation of adrenochrome, quinoproteins and GSH-adduct. Chem. Res. Tox. 20, 1183-1191.

Duarte IF, Goodfellow BJ, Barros A, Jones JG, Barosa C, Diogo L, Garcia P, and Gil AM. (2007) Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high resolution 1H NMR spectroscopy. NMR in Biomedicine, 20, 401-412.

Figueiras A, Carvalho RA, Ribeiro L, Torres-Labandeira JJ, Veiga FJB. (2007) Solid-state characterization and dissolution characteristics on the inclusion complex of omeprazole with native and chemically modified -cyclodextrin. Eur. J. Pharm. Biopharm. 67, 531-539.

Montezinho LP, Mørk A, Duarte CB, Penschuck S, Geraldes CFGC, Castro MMCA. (2007) Effect of mood stabilizers on dopamine D2-like receptors-mediated inhibition of adenylate cyclase. Bipolar Disorders, 9: 290-297.

Norek M, Pereira GA, Geraldes CFGC, Denkova A, Zhou W,  Peters JA. (2007) NMR Transversal Relaxivity of Suspensions of Lanthanide Oxide Nanoparticles. J. Phys. Chem. C, 111: 10240-10246.

Rafael AI, Almeida A, Santos P, Parreira I, Madeira VMS, Alves R, Cabrita MAS, Alpoim MC. (2007) A role for transforming growth factor- apoptotic signaling pathway in liver injury induced by ingestion of water contaminated with high levels of Cr(VI). Toxicol. Appl. Pharmacol., 224, 163-173.

Ramírez, BG, Rodrigues, TB, Violante, IR, Cruz, F, Fonseca, LL, Ballesteros, P, Castro, MMCA, García-Martín, ML, Cerdán, S. (2007) Kinetic Properties of the Redox Switch/Redox Coupling Mechanism as Determined in Primary Cultures of Cortical Neurons and Astrocytes from Rat Brain. J. Neurosci. Res. 853244-3253.

Rodrigues TB, Cerdan S, García-Martín ML. (2007) A method to measure lactate recycling by edited 1H NMR spectroscopy. Anal Biochem. 370: 246-248.

Rodrigues, TB, Granado, N, Ortiz, O, Cerdan, S, Moratalla, R. (2007) Metabolic Interactions between glutamatergic and dopaminergic neurotransmitter systems are mediated through D1, but not D2, dopamine receptors. J. Neurosci. Res. 85: 3284-3293.

Rodrigues, TB, Cerdán S. (2007) The cerebral Tricarboxylic Acid Cycles. In: Handbook of Neurochemistry and Molecular Neurobiology. Vol. 5: Brain Energetics from Genes to Cells, Integration of Molecular and Cellular Processes. Lajtha A., Gybson G., Dienel G., editors. Springer, New York. pp. 63-92.

Sena C, Ceiça R, Barosa C, Nunes E, and  Jones JG. (2007) Sources of endogenous glucose production in the Goto-Kazizaki diabetic rat.  Diabetes & Metabolism, 33, 296-302.

Soares AFL, Carvalho RA, Veiga FJB. (2007) Oral administration of peptides and proteins: nanoparticles and cyclodextrins. Nanomedicine 2, 183-202.

Tomé AR, Castro E, Santos RM, Rosário LM. (2007) Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP. BMC Neuroscience 8:41

Tomé AR, Castro E, Santos RM, Rosário LM. (2007) Functional distribution of Ca2+-coupled P2 purinergic receptors among adrenergic and noradrenergic bovine adrenal chromaffin cells. BMC Neuroscience 8:39

Torres S, Martins JA, André JP, Neves M, Santos AC, Prata MIM, Geraldes CFGC. (2007) Radiolabelled Sm-153 Chelates of Glycoconjugates: Multivalence and Topology Effects on the Targeting of the Asialoglycoprotein Receptor. Radiochimica Acta, 95: 343-349.



Cell and Development Biology


Amaral A, Ramalho-Santos J, St John JC The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm. Hum Reprod. 22:1585-1596.

Cruz MT Gonçalo M, Figueiredo A, Duarte CB, and Lopes MC. (2007) Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: role of different immunosuppressive drugs. Immunopharmacol. and Immunotoxicol., , 29: 225-241.

Dourado M, Sarmento A, Pereira SV, Alves V, Silva T, Mota Pinto A, Santos Rosa M. (2007) CD26/DPPIV expression and 8-azaguanine response in T-Acute Lymphoblastic Leukaemia Cell lines in Culture. Pathophysiology 14: 143–10.

Halter D, Neumann S, van Dijk SM, Wolthoorn J, Mazière AM, Vieira OV, Mattjus P, Klumperman J, van Meer G, Sprong H. (2007) Pre- and Post-Golgi Translocation of Glucosylceramide in Glycosphingolipid Synthesis. J. Cell Biol. 179(1):101-115.    

Judas F, Rosa S, Teixeira L, Lopes C, Mendes AF. (2007) Chondrocyte viability in fresh and frozen large human osteochondral allografts: effect of cryoprotective agents. Transplant. Proc. 39: 2531-2534.

Ramalho-Santos J, Amaral A, Sousa AP, Rodrigues AS, Martins L, Baptista M, Mota PC, Tavares R, Amaral S, Gamboa S. (2007) Probing the Structure and Function of Mammalian Sperm using Optical and Fluorescence Microscopy. In Modern Research and Educational Topics in Microscopy, Volume I (A. Méndez-Vilas and J. Díaz, Eds) Formatex, pp-394-402.

Sarmento-Ribeiro AB, Costa C, Casalta JE, Andrade C, Oliveira A, Moreira D, Gonçalves AC, Alves V, Silva T, Dourado M. (2007) Farnesyltransferase Inhibitors as a New Therapeutic Approach in Acute Lymphoblastic Leukemia. Haematologica 92 (s1): 416-417

Varum S, Bento C, Sousa AP, Gomes-Santos CS, Henriques P, Almeida-Santos T, Teodosio C, Paiva A, Ramalho-Santos J. Characterization of human sperm populations using conventional parameters, surface ubiquitination, and apoptotic markers. Fertil Steril 87:572-583.

Viegas M, Martins TC, Seco F, Carmo A. (2007) An improved and cost effective methodology for the reduction of autofluorescence in direct immunofluorescence studies on formalin-fixed paraffin-embedded tissues Eur. J. Histochemistry 51: 59-66.

Viegas M, Carmo A, Silva T, Seco F, Serra V, Lacerda M, Martins TC. (2007)  CD38 plays a role in effective containment of mycobacteria within granulomata and polarization of Th1 immune responses against Mycobacterium avium. Microbes and Infection 9: 847-854.

Vital L, Tabernero M D, Crespo I, Rebelo O, Tão H, Gomes F, Castrillo A, Lopes M C, Orfão A. (2007) Analysis of chromosome abnormalities by interphase fluorescence in situ hybridization (FISH) and gene expression profiles in human gliomas.  Chromosome Res. 15, 1, 212-213.