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| Molecular Mechanisms of Disease |
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| Research Interests |
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| Our research aim is to unravel the cellular and molecular mechanisms underlying neurodegeneration in pathologies characterized by aberrant peptide accumulation, namely Alzheimer´s and Parkinson´s diseases. The impact of some risk factors, particularly aging and diabetes, is also studied. The main focus of our ongoing projects is the signaling pathways mediated by mitochondria and endoplasmic reticulum, namely quality control systems and oxidative stress. Ultimately, our goal is to identify novel strategies for therapeutic intervention that may delay or even stop the neurodegenerative process in these disorders. Our know-how, together with our (inter)national collaborations, give us the tools needed for the development of translational approaches that may accelerate the bench to bedside transference of knowledge. The ongoing projects are based on the use of several models including mitochondrial-DNA depleted and cybrid cell lines, primary neuronal and endothelial cultures and cell lines, transgenic mice, isolated mitochondria, human brain and peripheral samples (Fig. 1). |
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Fig. 1 - In vitro and in vivo models |
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CLÁUDIA MARIA FRAGÃO PEREIRA, PhD
Domain of Specialization
Endoplasmic reticulum (ER) stress response in neurodegeneration.
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SANDRA MORAIS CARDOSO, PhD
Domain of Specialization
Mitochondria regulation of cellular quality control systems in Parkinson’s disease and Alzheimer´s diseases.
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PAULA I. MOREIRA, PhD
Domain of Specialization
Mitochondrial dysfunction, oxidative stress and insulin signaling impairment in brain aging, Alzheimer’s disease and diabetes.
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