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| Cláudia Cavadas |
| Group Leader |
Assistant Professor
Faculty of Pharmacy
University of Coimbra |
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+351 963928766 |
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| Ongoing Projects |
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Neuropeptide Y in the retina: Why? What for?
Principal Investigator: Cláudia Cavadas
Support: Foundation for Science and Technology (FCT), Portugal
Ref: PTDC/SAU-NEU/73119/2006
May 2007 - April 2010
Regulation of AMPA receptors by hyperglycemia in the retina
Principal Investigator: António Francisco Ambrósio
Support: Foundation for Science and Technology (FCT), Portugal
Ref: PTDC/SAU-NEU/71228/2006
June 2007 - May 2010
Nanomedicine and new therapeutic strategies: Development of supramolecular structures for the treatment of ocular diseases
Principal Investigator: António Francisco Ambrósio
Support: Comissão de Coordenação e Desenvolvimento Regional do Centro
January 2007 – December 2008
Evaluation of ecstasy-induced toxicity in the rat retina: in vitro and in vivo studies
Principal Investigators: Cláudia Cavadas and António Francisco Ambrósio
Support: Faculty of Medicine, University of Coimbra
Ref: GAI 01/07
January 2007 - December 2007
ATP and diabetic retinopathy: role on microglia regulation and on neuronal cell death
Principal Investigator: Paulo Santos
Support: Foundation for Science and Technology (FCT), Portugal
Ref: POCTI/SAU-NEU/59003/2004
March 2005 - February 2008
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| Collaborations |
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Alistair Barber and David Antonetti, Penn State Retina Research Group, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Ben Bahr, Department of Pharmaceutical Sciences and The Neurosciences Program, University of Cunnecticut, Storrs, CT, USA.
Eric Grouzmann, Division of Clinical Pharmacology and Toxicology, Lausanne University Medical School, 1011, Lausanne, Switzerland.
John Forrester, Department of Ophthalmology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
Michael J. Young, The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Patrik Brundin, Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.
Willem Kamphuis, Netherlands Institute for Neuroscience (NIN)-KNAW, Department of Astrocyte Biology and Neurodegeneration, Amsterdam, The Netherlands.
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| Publications |
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Alvaro AR, Rosmaninho-Salgado J, Ambrósio AF, Cavadas C. Neuropeptide Y inhibits [Ca(2+)](i) changes in rat retinal neurons through NPY Y(1), Y(4) and Y(5) receptors. J Neurochem. 2009 Apr 1 (in press)
Rosmaninho-Salgado J, Araújo IM, Alvaro AR, Mendes AF, Ferreira L, Grouzmann E, Mota A, Duarte EP, Cavadas C. Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide. J Neurochem. 2009 Mar 2. (in press)
Álvaro A.R., J. Martins, A.C. Costa, E. Fernandes, F. Carvalho, A.F. Ambrósio, C. Cavadas. (2008) Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy. Neuroscience, 152:97-105.
Álvaro AR, Martins J, Araújo IM, Rosmaninho-Salgado J, Ambrósio AF, Cavadas C. (2008) Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide. J Neurochem 105:2501-2510.
Araújo IM, Gil J, Carreira BP, Mohapel P, Petersén Å, Pinheiro PS, Soulet D, Bahr BA, Brundin P, Carvalho CM (2008) Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus. J Neurochem 105:666-676.
Leal E.C., C.A. Aveleira, A.F. Castilho, F.I. Baptista, A.F. Ambrósio. (2008) Muller cells do not influence leukocyte adhesion to retinal endothelial cells. Ocul. Immunol. Inflamm., 16:173-179.
Santiago AR, Carvalho, CM, Carvalho AP, Ambrósio, AF (2008). Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons. Neurochem Res 33: 1501-1508.
Santiago, A.R J.M. Hughes, W. Kamphuis, R.O. Schlingemann and A.F Ambrósio. (2008) Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina. Brain Res., 1198:153-159.
Santiago AR, Cristóvão AJ, Santos PF, Carvalho CM, Ambrósio AF. (2007) High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol. Dis. 25:464-472.
Araújo IM, Carreira BP, Pereira T, Santos PF, Soulet D, Inácio A, Bahr BA, Carvalho AP, Ambrósio AF, Carvalho CM. (2007) Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons. Cell Death Differ. 14:1635-1646.
Álvaro AR, Rosmaninho-Salgado J, Santiago AR, Martins J, Aveleira C, Santos PF, Pereira T, Gouveia D, Carvalho AL, Grouzmann E, Ambrósio AF, Cavadas C. (2007) NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells. Neurochem. Int. 50: 757-763.
Rosmaninho-Salgado J, Araújo I, Álvaro AR, Duarte EP, Cavadas C. (2007) Intracellular signalling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells. J. Neurochem. 103: 896-903.
Rosmaninho-Salgado J, Alvaro AR, Grouzmann E, Duarte EP, Cavadas C. (2007) Neuropeptide Y regulates catecholamine release evoked by interleukin-1β in mouse chromaffin cells. Peptides 28:310-314.
Santiago AR, Rosa SC, Santos PF, Cristóvão AJ, Barber AJ, Ambrósio AF. (2006) Elevated glucose changes the expression of ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells. Invest. Ophthalmol. Vis. Sci. 47:4130-4137.
Santiago AR, Garrido MJ, Santos PF, Cristóvão AJ, Ambrósio AF. (2006) High glucose and diabetes increase the release of [3H]-D-aspartate in retinal cell cultures and in rat retinas. Neurochem. Int. 48:453-458.
Cavadas C, D. Cefai, J. Rosmaninho-Salgado, M.A. Vieira-Coelho, E. Moura, N. Busso, T. Pedrazzini, D. Grand, S. Rotman, B Waeber, J.F. Aubert and E. Grouzmann. Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Proc. Natl. Acad. Sci. USA 2006, 103:10497-10502.
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