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| João Laranjinha |
| Group Leader |
Associate Professor
Faculty of Pharmacy
University of Coimbra |
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| Relevant publications |
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Lourenço, C.F., Santos, R., Barbosa, R.M., Gerhardt, G., Cadenas, E., Laranjinha, J. (2010) In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus. Hippocampus, in press.
Ledo, A., Barbosa, R., Cadenas, E., Laranjinha, J. (2010) Dynamic and Interacting profiles of ⋅NO and O2 in rat hippocampal slices. Free Radic Biol Med, 48(8):1044-50
Rocha BS, Gago B, Barbosa RM, Laranjinha J. (2010) Diffusion of nitric oxide through the gastric wall unpon reduction of nitrite by red wine: physiological impact. Nitric Oxide, 22(3):235-41.
Rocha BS, Gago B, Barbosa RM, Laranjinha J. (2009) Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology, 265(1-2):41-8.
Frade JG, Barbosa RM, Laranjinha J. (2009) Stimulation of NMDA and AMPA glutamate receptors elicts distinct concentration dynamics of nitric oxide in rat hippocampal slices. Hippocampus, 19(7):603-11.
Brito PM, Devillard R, Nègre-Salvayre A, Almeida LM, Dinis TC, Salvayre R, Augé N. (2009) Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis, 205(1):126-34.
Gago B, Nyström T, Cavaleiro C, Rocha BS, Barbosa RM, Laranjinha J, Lundberg JO. (2008) The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. Free Radic Biol Med., 45(4):404-12.
Santos RM, Lourenço CF, Piedade AP, Andrews R, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J, Barbosa RM. (2008) A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue. Biosens Bioelectron. 24(4):704-9.
Barbosa RM, Lourenço CF, Santos RM, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J. (2008) In vivo real-time measurement of nitric oxide in anesthetized rat brain. Methods Enzymol. 441:351-67.
Nunes C, Almeida L, Laranjinha J. (2008) 3,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning. Neurotoxicology, 29(6):998-1007.
Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pocock J, Laranjinha J, Heales S. (2008) Glutamate induced release of glutathione from culture rat astrocytes - a possible neuroprotective mechanism? J Neurochem., 105(4):1144-52.
Brito PM, Simões NF, Almeida LM, Dinis TC. (2009) Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2. Apoptosis, 13(8):1043-53.
Bruno Gago, Jon O. Lundberg, Rui M. Barbosa and João Laranjinha (2007) Red wine-dependent reduction of nitrite to nitric oxide in the stomach. Free Radic Biol Med. 43(9):1233-42.
Laranjinha, J. and Ledo, A (2007) Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria. Frontiers in Bioscience, 12, 1094-106.
Ana Ledo, Rui M. Barbosa, Greg A. Gerhardt, Enrique Cadenas, and João Laranjinha (2005) Concentration dynamics of nitric oxide in rat hippocampal sub regions evoked by stimulation of the NMDA glutamate receptor. Proceedings of the National Academy of Sciences of the USA, 102, 17483-17488.
Nunes, C., Almeida, L., Laranjinha, J. (2005) Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC). Implications for Parkinson´s disease. Neurochemistry International. 47, 173-182.
Nuno R. Ferreira, Ana Ledo, João G. Frade, Greg A. Gerhardt, João Laranjinha, Rui M. Barbosa (2005). Electrochemical measurement of endogenously-produced nitric oxide in brain slices using o-phenylenediamine-modified carbon fiber microelectrodes Analytica Chimica Acta, 535, 1-7.
Martins J, Almeida L. and Laranjinha J. (2004) Simultaneous production of superoxide radical and singlet oxygen by sulphonated chloroaluminum phthalocyanine incorporated in human low density lipoproteins. Implications for photodynamic therapy. Photochem & Photobiol. 80, 267-273.
Laranjinha, J., Cadenas, E. (2002) Oxidation of DOPAC by nitric oxide. Effect of superoxide dismutase. Journal of Neurochemistry 81, 892-900.
Laranjinha, J. and Cadenas, E. (1999) Redox cycles of caffeic acid, a-tocopherol, and ascorbate. Implications for LDL protection against oxidation. IUBMB Life 48, 1-9.
Laranjinha, J., Vieira, O., Madeira, V. and Almeida, L. (1995) Two related phenolic antioxidants with opposite effects on vitamin E content in low density lipoproteins oxidized by ferrylmyoglobin: consumption vs regeneration. Archives of Biochemistry and Biophysics 323, 373-381.
Laranjinha, J., Almeida, L. and Madeira, V. (1994) Reactivity of dietary phenolic acids with peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation. Biochemical Pharmacology 48, 487-494. |
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| Group Leader Curriculum Vitae |
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Education:
2006 “Agregação” Faculty of Pharmacy, University of Coimbra, Portugal.
1996 Ph.D., Biochemistry, Faculty of Pharmacy, University of Coimbra, Portugal.
1987 Proof of Pedagogic Aptitude and Scientific Capacity (academic degree equivalent to Master degree in Portugal), Faculty of Pharmacy, University of Coimbra, Portugal.
1984 Graduated in Pharmaceutical Sciences (6 years degree), Faculty of Pharmacy, University of Coimbra, Portugal. |
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Positions:
2009-2011 Council” do comité da European Society for Neurochemistry
2008-2010 Secretary General of Portuguese Biochemical Society
2007-2010 Member of the European Committee of the Society for Free Radical Research
2005-2007 General Secretary of the General Assembly of Portuguese Biochemical Society
2005 - Director of the Center for Sensor Technology – Coimbra Labs Divison. (University of Kentucky, Lexington, USA)
2005 - Coordinator of the Free radical Group of the Portuguese Biochemical Society
2004- Group leader: Free Radicals and Antioxidants, Center for Neurosciences and Cell Biology, Coimbra
2002- Associate Professor, Faculty of Pharmacy, University of Coimbra.
1997-1998 Post-doctoral Research Fellow, Dept. Molecular Pharmacology & Toxicology, University Southern California, Los Angeles, USA
1996-2005 Assistant-Professor of Biochemistry, Faculty of Pharmacy, University of Coimbra
1989-1996 Assistant of Biochemistry, Faculty of Pharmacy, University of Coimbra
1989-1996 Assistant of Biochemistry, Faculty of Pharmacy, University of Coimbra
1984-1989 Teaching-Assistant of Biochemistry, Faculty of Pharmacy, University of Coimbra
1984 Monitor, Faculty of Pharmacy, University of Coimbra |
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Awards and fellowships:
1997-1998 Recipient of a Fellowship from Luso-American Foundation for Development (Portugal)
1997-1998 Recipient of a Fellowship from Junta Nacional de Investigação Cientifica (Portuguese Government)
1997 1st. prize Merck Sharp & Dohme VII Portuguese Congress on Atherosclerosis, “New biochemical mechanisms in atherosclerosis” |
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| Links |
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João Laranjinha webpage
http://www.ff.uc.pt/~laranjin/ |
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Society for Free Radical Research – Europe
http://www.sfrr-europe.org |
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Society for Free Radical Biology and Medicine - USA
http://www.sfrbm.org/ |
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Portuguese Society of Biochemistry
http://www.spb.pt/ |
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