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João Ramalho-Santos
Ph.D. |
| Group Leader |
Center for Neuroscience
and Cell Biology
Department of Life
Sciences
University of Coimbra
P.O. Box/Apartado 3046
3001-401 Coimbra
PORTUGAL |
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Ph. |
+ 351(239)-855 760 |
| Fax |
+ 351(239)-855 789 |
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| Collaborations |
Miguel Ramalho-Santos, University of California San Francisco USA; Gerald Schatten University of Pittsburgh, USA & Christopher Navara, Univeristy of Texas San Antonio, USA (embryonic stem cell pluripotency)
Stefan Schlatt, University of Pittsburgh, USA (testicular stem cells)
L. Gabriel Sanchez-Partida, Monash University, Australia (freeze-dried sperm)
Paulo J. Oliveira, Centro de Neurociências e Biologia Celular (mitochondrial bioenergetics in the testis)
Otília Vieira, Centro de Neurociências e Biologia Celular (detergents as possible spermicides)
Albertina Freitas & Artur Paiva, Centro de Histocompatibilidade do Centro (characterization of sperm subpopulations by flow cytometry and cell sorting)
M. Lourdes Pereira, Universidade de Aveiro (reproductive toxicology).
Vasco Almeida, University of Oporto; Helena Figueiredo, Gaia Hospital & Juan Felipe Velez de la Calle, Clinique Pasteur, Brest, France (human sperm quality)
João Arriscado Nunes, Centro de Estudos Sociais, Universidade de Coimbra (science and society)
Sandra Gamboa, Escola Superior Agrária de Coimbra (reproduction in horses)
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| Selected Publications |
Energy metabolism of human pluripotent stem cells and their differentiated counterparts (2011) Sandra Varum, Ana Sofia Rodrigues, Michelle B. Moura, Olga Momcilovic, Charles Easley, João Ramalho-Santos, Bennett Van Houten & Gerald Schatten. PLoS ONE 6 (6): e20914.
Not all sperm are equal: Functional mitochondria characterize a subpopulation of human sperm with better fertilization potential (2011) Ana Paula Sousa, Alexandra Amaral, Marta Baptista, Renata Tavares, Pedro Caballero-Campo, Pedro Caballero-Peregrín, Albertina Freitas, Artur Paiva, Teresa Almeida-Santos & João Ramalho-Santos. PLoS ONE 6(3): e18112.
Human procreation in unchartered territory: New twists in ethical discussions (2011) João Ramalho-Santos.. Human Reproduction 26: 1284-1287.
Metabolic remodeling during H9c2 myoblast differentiation: Relevance for in vitro toxicity studies (2011) Sandro Pereira, João Ramalho-Santos, Ana F. Branco, Vilma A. Sardão, Paulo J. Oliveira & Rui A. Carvalho. Cardiovascular Toxicology11: 180-190.
Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain (2009) Sandra Varum, Olga Momcilovic, Carlos Castro, Ahmi Ben-Yehudah, João Ramalho-Santos* & Christopher S. Navara* (*co-corresponding authors). Stem Cell Research 3: 142-156.
Mitochondrial functionality and reproduction: From gonads and gametes to embryos and embryonic stem cells (2009) João Ramalho-Santos, Sandra Varum, Sandra Amaral, Paula C. Mota, Ana Paula Sousa & Alexandra Amaral. Human Reproduction Update 5: 553-572.
Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin status (2009) Ana Paula M. Sousa, Renata S. Tavares, Juan Felipe Velez de la Calle, Helena Figueiredo, Vasco Almeida, Teresa Almeida-Santos & João Ramalho-Santos Human Reproduction 24:28-36.
Testicular aging involves mitochondrial dysfunction and UCP2-mediated proton leak (2008) Sandra Amaral, Paula Mota, Ana Sofia Rodrigues, Luís Martins, Paulo J. Oliveira & João Ramalho-Santos. FEBS Letters 582:4191-4196
The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm (2007) Alexandra Amaral, João Ramalho-Santos & Justin St. John. Human Reproduction 22:1585-1596.
The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells (2005) Justin St. John*, João Ramalho-Santos*, Heather Gray, Christopher Navara, Vanesa Y. Rawe, Patti Petrosko, Calvin Simerly & Gerald Schatten (*Co-first authors). Cloning & Stem Cells 7:141-153.
ICSI choreography: Fate of sperm structures after monospermic ICSI and first cell cycle implications (2001) João Ramalho-Santos, Peter Sutovsky, Calvin R. Simerly, Richard Oko, Gary M. Wessel, Laura Hewitson & Gerald Schatten, Human Reproduction, 15: 2610-2620.
Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis (2001) João Ramalho-Santos, Ricardo D. Moreno, Gary M. Wessel, Edward K. L. Chan & Gerald Schatten, Experimental Cell Research, 267: 45-60.
SNAREs in mammalian sperm: Possible implications for fertilization (2000) João Ramalho-Santos, Ricardo D. Moreno, Peter Sutovsky, Anthony Wing-Sang Chan, Laura Hewitson, Gary M. Wessel, Calvin R. Simerly & Gerald Schatten, Developmental Biology, 223: 54-69.
Ubiquitin tag for sperm mitochondria (1999) Peter Sutovsky, Ricardo D. Moreno, João Ramalho-Santos, Tanja Dominko, Calvin Simerly & Gerald Schatten, Nature, 402: 371-372.
Unique checkpoints during the first cell cycle of fertilization after intracytoplasmic sperm injection in rhesus monkeys (1999) Laura Hewitson, Tanja Dominko, Diana Takahashi, Crista Martinovich, João Ramalho-Santos, Peter Sutovsky, John Fanton, Darla Jacob, Daymond Monteith, Martha Neuringer, David Battaglia, Cal Simerly & Gerald Schatten, Nature Medicine, 5: 431-433.
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| Curriculum Vitae |
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PI Current Positions:
Associate Editor Human Reproduction Update 2007- present. |
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PI Education and Previous Positions:
Fulbright Fellow, University of California San Francisco, USA
Associate Editor Human Reproduction: 2001-2006
Visiting Scientist at the Magee-Women’s Research Institute, University of Pittsburgh, USA, 2002-2006
Postdoctoral fellow at the Oregon National Primate Research Center (Oregon Health Sciences University), Portland, Oregon, USA, 1997-2000
Ph.D. in Cell Biology at the University of Coimbra, Portugal (1997). Research conducted at the Center for Neuroscience and Cell Biology
Visiting Graduate Student, University of Groningen, The Netherlands (1989)
B.Sc. in Biology at the University of Coimbra, Portugal (1988)
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