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Colaborações
Ann Marie Craig
Brain Research Centre, University of British Columbia, Vancouver, Canada
Carlos N Pato
University of Southern California, Los Angeles, USA
Chinfei Chen
Harvard Medical School, Boston, USA
Jenni Harvey
University of Dundee, Dundee, UK
José Esteban
Centro de Bíologia Molecular Severo Ochoa – CSIC, Universidad Autómona de Madrid, Madrid, Spain
Laurent Groc
Interdisciplinary Neuroscience Institute, Bordeaux, France
Miguel Marques
University of Lyon 1, Lyon, France
Célia Barreto Carvalho
University of Azores, Ponta Delgada, Portugal
Fernando Nogueira
Physics Department, University of Coimbra, Coimbra, Portugal
Patrícia Maciel
Life and Health Sciences Research Institute, University of Minho, Braga, Portugal
Sandra de Macedo-Ribeiro
IBMC, University of Porto, Porto, Portugal
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Áreas de interesse
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O nosso cérebro é constituído por milhares de milhões de neurónios que comunicam em pontos de contacto designados por sinapses. As memórias, os pensamentos e o comportamento no geral estão codificados em alterações na intensidade de comunicação sináptica. O nosso grupo está interessado nos mecanismos celulares e moleculares da função sináptica e da plasticidade sináptica, e em como disfunção sináptica e dos circuitos neuronais está na base de doenças neuropsiquiátricas e neurodegenerativas.
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Cellular and molecular mechanisms of synaptic function and plasticity
(PI: Ana Luisa Carvalho)
Neuronal circuits and behavior
(PI: João Peça)
Neurosecretion
(PI: Paulo Pinheiro)
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| Ana Luísa Carvalho |
| PhD |
| Líder de Grupo |
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| João Peça |
| PhD |
| Investigador Principal |
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| Paulo Pinheiro |
| PhD |
| Investigador Principal |
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| Sandra D Santos |
| MD, PhD |
| Gestor de laboratório |
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| Joana Guedes |
| PhD |
| Bolseiro de Pós Doutoramento |
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| Dominique Fernandes |
| PhD |
| Bolseiro de Pós Doutoramento |
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| Mariline Silva |
| PhD |
| Bolseiro de Pós Doutoramento |
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| Gladys Caldeira |
| PhD |
| Bolseiro de Pós Doutoramento |
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| Mohamed Edfawy Hussien |
| PhD |
| Bolseiro de Pós Doutoramento |
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| Ângela Inácio |
| PhD |
| Bolseiro de Pós Doutoramento |
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| Mário Carvalho |
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| Aluno de Doutoramento |
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| Jeannette Schmidt |
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| Aluno de Doutoramento |
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| Nuno Beltrão |
| Assistente de Investigação |
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| Débora Serrenho |
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| Aluno de Doutoramento |
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| Marina Rodrigues |
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| Aluno de Doutoramento |
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| Beatriz Rodrigues |
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Antigos membros
André R Gomes – now CEO at Crioestaminal, Biocant, Cantanhede
Bruno Cruz – now PhD student at the Champalimaud Foundation, Lisbon
Carlos Matos – now Post-doctoral Fellow at the Vectors and Gene Therapy Group, CNC, Coimbra
Fabio Mazza
Joana Fernandes – now Science and Research Writer at BioNews Services
Joana S Ferreira – now Post-doctoral Fellow at IINS, University of Bordeaux, France
Joni Fiona van Leeuwen – now at Cabo da Roca International Language School
Luis Ribeiro – now Post-doctoral Fellow at VIB, Leuven, Belgium
Marilisa Vigorita – now PhD student at the Università degli Studi del Sannio, Italy
Marta Vieira – now Post-doctoral Fellow at NIH, Bethesda, USA
Nuno Andrade – now Head of Research Support Office at the Childrens Cancer Research Institute, Vienna, Austria
Olga Iuliano – now PhD student at Institut Curie, Paris, France
Pedro Rio – now Biotech Sales Representative at NZYTech
Rodolfo Águas
Susana Louros – now Research Assistant at the Center for Integrative Physiology, University of Edinburgh, UK
Susana S Correia – now Scientist II at Ironwood Pharmaceuticals, Boston, USA
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Publicações seleccionadas
Lima Caldeira G, Peca J, Carvalho AL. (2019) New insights on synaptic dysfunction in neuropsychiatric disorders. Curr Opin Neurobiol 57: 62-70.
Silva M, Rodrigues B, Fernandes J, Santos SD, Carreto L, Santos M, Pinheiro P, Carvalho AL. (2019) MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons. PNAS 116(12): 5727-5736.
Fernandes D, Santos SD, Coutinho, E, Whitt JL, Rondão T, Leite MI, Buckley C, Lee HK, Carvalho AL. (2019) Disrupted AMPA receptor function upon genetic or antibody-mediated loss of autism-associated CASPR2. Cerebral Cortex DOI: 10.1093/cercor/bhz032 [Epub ahead of press]
Kellermayer B, Ferreira JS, Dupuis J, Levet F, Grillo-Bosch D, Bard L, Linares-Loyez J, Bouchet D, Choquet D, Rusakov DA, Bon P, Sibarita JB, Cognet L, Sainlos M, Carvalho AL, Groc L (2018) Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses. Neuron 100: 106-119 e107.
Louros SR, Caldeira GL, Carvalho AL (2018) Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses. Front Mol Neurosci 11: 328.
Vieira, M. M., Schmidt, J., Ferreira, J. S., She, K., Oku, S., Mele, M., Santos, A. E., Duarte, C. B., Craig, A. M., and Carvalho, A. L. (2016) Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia. Neurobiol Dis 89, 223-234.
Matos, C. A., Nobrega, C., Louros, S. R., Almeida, B., Ferreiro, E., Valero, J., Pereira de Almeida, L., Macedo-Ribeiro, S., and Carvalho, A. L. (2016) Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models. J Cell Biol 212, 465-480; comment in J Cell Biol 212, 355.
Ferreira JS, Schmidt J, Rio P, Aguas R, Rooyakkers A, Li KW, Smit AB, Craig AM, Carvalho AL (2015) GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome. J Neurosci 35: 8462-8479.
Louros S, Hooks B, Litvina L, Carvalho AL*, Chen C* (2014): A Role for Stargazin in Experience-Dependent Plasticity. Cell Reports 2014, 7: 1-12. *Corresponding authors.
Ribeiro LF, Catarino T, Santos SD, Benoist M, van Leeuwen JF, Esteban JA, Carvalho AL (2014) Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. Proc Natl Acad Sci U S A 111:E149-158.
Pinheiro PS, Jansen AM, de Wit H, Tawfik B, Madsen KL, Verhage M, Gether U, Sørensen JB (2014) The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells. J Neurosci. 34(32):10688-700.
Vergnano AM, Rebola N, Savtchenko LP, Pinheiro PS, Casado M, Kieffer BL, Rusakov DA, Mulle C, Paoletti P (2014) Zinc dynamics and action at excitatory synapses. Neuron. 82(5):1101-14.
Peca J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 2011, 472:437-442.
ver mais
Almeida B, Abreu IA, Matos CA, Fraga JS, Fernandes S, Macedo MG, Gutierrez-Gallego R, Pereira PJ, Carvalho AL, Macedo-Ribeiro S (2015) SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97. Biochim Biophys Acta 1852:1950-1959.
Catarino T, Ribeiro L, Santos SD, Carvalho AL (2013) Regulation of Synapse Composition by Protein Acetylation: The Role of Acetylated Cortactin. J Cell Sci. 126, 149–162.
Santos SD, Iuliano O, Ribeiro L, Veran J, Ferreira JS, Rio P, Mulle C, Duarte CB, Carvalho AL (2012) Contactin associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. J Biol Chem. 287(9):6868-77.
Peca J, Feng G (2012) Cellular and synaptic network defects in autism. Curr Opin Neurobiol. 2012 Oct;22(5):866-72
Ferreira JS, Rooyakkers A, She K, Ribeiro L, Carvalho AL*, Craig AM* (2011) Activity and protein kinase C regulate synaptic accumulation of NMDA receptors independently of GluN1 splice variant. J. Biol. Chem. 286(32):28331-42. *Corresponding authors.
Matos CM, Macedo-Ribeiro S*, Carvalho AL* (2011) Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease. Prog. Neurobiol. 95(1):26-48. *Corresponding authors.
Santos SD, Manadas B, Duarte CB, Carvalho AL (2010) Proteomic analysis of an interactome for long-form AMPA receptor subunits. J. Proteome Res. 9, 1670-1682.
Moult P, Cross A, Santos S, Carvalho AL, Lindsay Y, Connolly C, Irving A, Leslie N, and Harvey J (2010) Leptin regulates AMPA receptor trafficking via PTEN inhibition. J. Neurosci. 30, 4088-4101.
Macedo-Ribeiro S, Cortes L, Maciel P, and Carvalho AL (2009). Nucleocytoplasmic shuttling activity of ataxin-3. PLoS ONE 4, e5834.
Wang H, Peca J, Matsuzaki M, Matsuzaki K, Noguchi J, Qiu L, Wang D, Zhang F, Boyden E, Deisseroth K, et al.: High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:8143-8148.
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LÍDER DE GRUPO
Ana Luísa Carvalho
Professora Auxiliar
Departamento de Ciências da Vida
Universidade de Coimbra
Tlf: 239 820190
Fax: 239 822776
Curriculum Vitae
EDUCAÇÃO:
1993 BSc in Biochemistry, University of Coimbra
1999 PhD in Biochemistry (Molecular Biology), University of Coimbra
POSIÇÕES:
| 2004-present |
Tenured Assistant Professor, Department of Life Sciences, University of Coimbra; Group Leader, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal |
| 2006-2007 |
Visiting Assistant Professor, Department of Psychiatry, School of Medicine, University of British Columbia, Vancouver, BC, Canada |
| 1999-2004 |
Assistant Professor, Department of Zoology, University of Coimbra; Investigator, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal |
| 1999 |
Postdoctoral Fellow, Biomedical Institute for Research in Light and Image, University of Coimbra, Coimbra, Portugal |
| 1998 |
Visiting Student, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MA, USA; Advisor: Dr. Richard L. Huganir |
| 1994-1999 |
Ph.D. Student; Thesis: Regulation of AMPA-type glutamate receptors by phosphorylation: Characterization of GluR4 phosphorylation |
INVESTIGADORES PRINCIPAIS
João Peça Silvestre
Investigador Principal
Centro de Neurociências e Biologia Celular
Universidade de Coimbra
Tlf: 239 820190
Fax: 239 822776
Curriculum Vitae
Educação:
2001: Doutoramento em Biologia Celular, tese desenvolvida na Duke University
1999: Licenciatura em Bioquímica, Universidade de Coimbra
Posições:
| 2013: |
Investigador Assistente, Centro de Neurociências e Biologia Celular, Universidade de Coimbra |
| 2011-2012: |
Pós-doutoramento, McGovern Institute for Brain Research, MIT |
| 2005-2011: |
Aluno de Doutoramento, Departamento de Neurobiologia, Duke University Medical Center |
Prémios e Honras:
| 2004: |
Prémio: Bolsa de 4 anos individual de Doutoramento atribuída pela FCT |
| 2012: |
Prémio: “Translational Postdoctoral Fellowship” - Autism Speaks Foundation |
| 2013: |
Prémio: Investigador FCT, stribuído pela FCT |
| 2013: |
Prémio: Marie Curie Career Integration |
| 2014: |
Prémio: NARSAD Young Investigator, Brain and Behavior Research Foundation |
Paulo Pinheiro
Investigador Principal
Centro de Neurociências e Biologia Celular
Universidade de Coimbra
Tlf: 239 820190
Fax: 239 822776
Curriculum Vitae
Educação:
2001: Licenciatura em Biologia Aplicada, Universidade do Minho
2006: Doutoramento em Biologia Celular, Universidade de Coimbra
Posições:
| 2001-2006: |
Aluno de Doutoramento, Centro de Neurociências de Coimbra |
| 2006-2009: |
Pós-doutoramento, CNRS UMR 5091, Universidade de Bordéus |
| 2009-2014: |
Pós-doutoramento, Inst. De Neurociências e Farmacologia, Universidade de Copenhaga. |
Prémios e Honras:
| 2001: |
Prémio: Bolsa de Doutoramento de 4 anos, FCT |
| 2005: |
Prémio: melhor tese de investigação, Ass. Portuguesa de Doutorados em França |
| 2006: |
Prémio: Estímulo à Investigação Científica, Fundação Calouste Gulbenkian |
| 2007: |
Prémio: artigo destaque, Sociedade Portuguesa de Neurociências |
| 2010: |
Prémio: bolsa de investigação, 4 anos, Fundação Lundbeck, Dinamarca |
| 2010: |
Prémio: Marie Curie Intra-European Fellowship |
| 2012: |
Prémio: investigador FCT, FCT Portugal |
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