Metabolism, aging and disease
Cell Signaling and Metabolism in Disease
Metabolism, mitochondria and hormones in brain disorders

Principal Investigator

Paula I. Moreira

Assistant Professor
Faculty of Medicine
University of Coimbra



Ph: +351 239 820190
Fax: +351 239 822776


Post-doctoral investigators

Ana I. Duarte

Orcid ID: 0000-0002-0223-7867
ResearcherID: C-9936-2009

My research interests include: 1) the subcellular mechanisms underlying CNS dysfunction in cardiometabolic and neurodegenerative diseases (Huntington’s and Alzheimer’s diseases) and reproductive aging; 2) the neuroprotective potential of non-pharmacological and pharmacological approaches (namely anti-diabetes drugs).

Cristina Carvalho

Orcid ID: 0000-0001-5887-6417
ResearcherID: K-4432-2014

Previous studies from our laboratory demonstrate that mitochondria is a link between type 2 diabetes and Alzheimer’s disease. In this line, the main goal of my current work is to decipher the molecular mechanisms underlying type 2 diabetes (T2D)-associated neurodegeneration focusing on the potential link between mitochondria and WW-domain-containing oxidoreductase (WWOX1). Ultimately, my goal is to uncover new therapeutic targets that may help develop more effective therapeutic strategies to fight T2D-associated brain changes.

Sónia Correia

Orcid ID: 0000-0001-5360-2564
ResearcherID: M-5855-2018

My scientific career has been devoted to demystify the pathological basis of Alzheimer’s disease (AD) in order to identify new and feasible peripheral biomarkers for the early diagnosis of the disease and promising therapeutic targets able to counteract the AD symptomatology and neuropathology in a timely manner. I am particularly interested in unveiling the contribution of abnormal mitochondrial dynamics and hampered adaptive response triggered by the transcription factor hypoxia inducible factor 1α (HIF-1α) to the onset and progression of this devastating neurodegenerative disease.

Susana Cardoso

Orcid ID: 0000-0002-9866-933
ResearcherID: K-3415-2015

Presently, my work is devoted to investigate the possible neuroprotective effects of 2,4-dinitrophenol (DNP), a mitochondrial uncoupler, in different in vitro and in vivo models of Alzheimer´s disease. To achieve my goal several mitochondrial-related aspects and signaling pathways are being evaluated to dissect the mechanistic basis underlying neuronal protection afforded by DNP.

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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