Selected Publications
Pires, C.F., Rosa, F.F., Pereira, C.F. (2019) Understanding and modulating immunity with cell reprogramming. Frontiers in Immunology in press.
Silvério-Alves, R., Gomes, A.M., Kurochkin, I., Moore, K.A., Pereira, C.F. (2019) Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors. JoVE. Nov 4;(153).
Rosa, F.F. *, Pires, C.F. *, Kurochkin, I., Ferreira, A.G., Gomes, A.M., Palma, L.G., Shaiv, K., Solanas, L., Azenha, C., Papatsenko, D., Schulx, O., Reis e Sousa, C., Pereira, C.F. (2018) Direct reprogramming of fibroblasts into antigen-presenting dendritic cells. Science Immunology 7, 3(30). *equal contribution. -Cover Science Immunology issue December 2018. Preview by Yona & Mildner, issue December 2018.
Gomes, A.M., Kurochkin, I., Chang, B.; Daniel, M., Law, K., Satija, N., Lachmann, A., Wang, Z., Ferreira, L., Ma’ayan, A., Chen, B.K., Papatsenko, D., Lemischka, I.R., Moore, K.A., Pereira, C.F. (2018) Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming. Cell Reports 25, 2821-25.
Kirkeby, A., Perlmann, T., Pereira, C. F *. (2016) The stem cell niche finds its true north. Development. *corresponding author.
Pereira, C.F.*; Chang, B.; Papatsenko, D.; Gomes, A.; Bernitz, B.; Niu, X.; Swiers, G.; Azzoni, E.; Brujin M.F.T.R.; Schaniel, C.; Lemischka, I.R.; Moore, K.A. (2016) Identification of Hemogenic Precursors in Placenta that Give Rise to Definitive Hematopoietic Stem Cells In Vivo is Informed by Hematopoietic Reprogramming In Vitro. Developmental Cell 36, 525-39. *corresponding author.
- Preview by Calvanese & Mikkola, 2016.
Pereira, C.F. *, Chang, B., Qiu, J., Niu, X., Papatsenko D., Hendry, C.E., Clark, N.R., Nomura-Kitabayashi, A., Kovacic, J., Ma’ayan A., Schaniel C., Lemischka, I.R., Moore, K.A. (2013) Induction of a Hemogenic Program in Mouse Fibroblasts. Cell Stem Cell 13, 205-18. *corresponding author. -Cover Cell Stem Cell issue August 2013. Preview by Pfaff & Cantz, 2013. -Highlighted in Molecular Therapy 21, 1291 (2013), Stem cells Translational Medicine News section June 2013. -Recommended by the Faculty of 1000.
Pereira C.F. *, Lemischka I.R., Moore K.A. (2012) Reprogramming cell fates: insights from combinatorial approaches. Ann. N. Y. Acad. Sci. 1266, 7-17. *corresponding author.
Pereira, C.F., Piccolo, F.M., Tsubouchi, T., Sauer, S., Ryan, N.K., Bruno, L., Landeira, D., Santos, J., Banito, A., Gil, J., Koseki, H., Merkenschlager, M., Fisher, A.G. (2010). ESCs require PRC2 to direct the successful reprogramming of differentiated cells towards pluripotency. Cell Stem Cell. 6, 547-556.
-Recommended by the Faculty of 1000
Covers

On the cover: "Induced" Dendritic Cells. In this issue, Rosa et al. report that ectopic expression of three transcription factors—PU.1, IRF8, and BATF3—is sufficient to reprogram mouse and human fibroblasts into "induced" dendritic cells. Featured on the cover is a colored scanning electron micrograph showing an "induced" dendritic cell with prominent cytoplasmic protrusions. CREDIT: JONAS AHLSTEDT & SEBASTIAN WASSERSTROM

On the cover: In this issue, Pereira et al. (205–218) describe the induction of hemogenesis in mouse fibroblasts via transduction of the transcription factors Gata2, cFos, Gfi1b, and Etv6. The cover is an artistic representation of this induction process. In a futuristic setting, a scientist programs a computer to program blood, leading to the formation of hemogenic blood vessels and subsequently blood. Cover design and illustration by Carlos-Filipe Pereira and Sandeep Menon.
Piccolo F.M., Pereira C.F., Cantone I., Brown K., Tsubouchi T., Soza-Ried J., Merkenschlager M., Fisher A.G. (2011). Using heterokaryons to understand pluripotency and reprogramming. Phil. Trans. R. Soc. 366, 2060-5
Pereira C.F (2011). Epigenetic events underlying somatic cell reprogramming: insights from heterokaryons. LAP LAMBERT Academic Publishing ISBN: 3846537144.
Schnetz, M.P., Handoko, L., Akhtar-Zaidi, B., Bartels, C.F., Pereira, C.F., Fisher, A.G., Adams, D.J., Flicek, P., Crawford, G.E., Laframboise, T., Tesar, P., Wei, C.L., Scacheri, P.C. (2010). CHD7 targets active enhancer elements to modulate ES cell-specific gene expression. Plos Genet. 15, e1001023.
Pereira, C.F., Piccolo, F.M., Tsubouchi, T., Sauer, S., Ryan, N.K., Bruno, L., Landeira, D., Santos, J., Banito, A., Gil, J., Koseki, H., Merkenschlager, M., Fisher, A.G. (2010). ESCs require PRC2 to direct the successful reprogramming of differentiated cells towards pluripotency. Cell Stem Cell. 6, 547-556. ˥Recommended by the Faculty of 1000.
Kanhere, A., Viiri, K., Araújo, C.C., Rasaiyaah, J., Bouwman, R.D., Whyte, W.A., Pereira, C.F., Brookes, E., Walker, K., Bell, G.W., Pombo, A., Fisher, A.G., Young, R.A., Jenner, R.G. (2010) Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell. 5, 675-88. ˥Recommended by the Faculty of 1000.
Landeira, D., Sauer, S., Poot, R., Dvorkina, M., Mazzarella, L., Jørgensen, H.F., Pereira, C.F., Leleu, M., Piccolo, F.M., Spivakov, M., et al. (2010). JARID2 is a PRC2 component in ES cells required for PRC1 and RNA Pol II recruitment at developmental regulator genes and multi-lineage differentiation. Nat. Cell Biol. , 6, 618-24.
Santos, J. *, Pereira, C.F. *, Di-Gregorio, A., Spruce, T., Alder, O., Rodriguez, T., Azuara, V., Merkenschlager, M., and Fisher, A.G. (2010). Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo. Epigenetics Chromatin 3, 1. *equal contributors.
Pereira, C.F., Fisher, A.G. (2009) Heterokaryon-based reprogramming for pluripotency. Curr. Protoc. Stem Cell Biol. Chapter 4:Unit 4B.1.
Savarese, F., Dávila, A., Nechanitzky, R., De La Rosa-Velazquez, I., Pereira, C.F., Engelke, R., Takahashi, K., Jenuwein, T., Kohwi-Shigematsu, T., Fisher, A.G., Grosschedl, R. (2009) Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev. 22, 2625-38.
Banito A., Rashid S.T., Acosta J.C., Li S., Pereira C.F., Geti I., Pinho S., Silva J.C., Azuara V., Walsh M., Vallier L., Gil J. (2009). Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 18, 2134-9.
Correia, M.P., Cardoso, E.M., Pereira, C.F., Neves, R., Uhrberg, M., Arosa, F.A. (2009). Hepatocytes and IL-15: a favorable microenvironment for T cell survival and CD8+ T cell differentiation. J Immunol. 182, 6149-59.
Jorgensen, H.F., Terry, A., Beretta, C., Pereira, C.F., Leleu, M., Chen, Z.F., Kelly, C., Merkenschlager, M., Fisher, A.G. (2009). REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development. 136, 715-721.
Pereira, C.F., Terranova, R., Ryan, N.K., Santos, J., Morris, K.M., Cui, W., Merkenschlager, M., Fisher, A.G. (2008). Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet. 4, e1000170.
Nunes, R.J., Castro, M.A., Gonçalves, C.M., Bamberger, M., Pereira, C.F., Bismuth, G., Carmo, A.M. (2008). Protein interactions between CD2 and Lck are required for lipid raft distribution of CD2. J. Immunol. 180, 988-997.
Terranova, R., Pereira, C.F., Du Roure, C., Merkenschlager, M., and Fisher, A.G. (2006). Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming. J. Cell Sci. 119, 2065-2072.
Cabrita, M.*, Pereira, C.F.*, Cardoso, E.M., Arosa, A. (2005). Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading. FEBS J. 272, 152-165 *equal contributors.
Arosa, F.A., Pereira, C.F., Fonseca, A.M. (2004). Red blood cells as modulators of T cell growth and survival. Curr. Pharm. Des. 10, 191-201.
Fonseca, A.M., Pereira, C.F., Porto, G., Arosa, F.A. (2003). Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds. Cell. Immunol. 224, 7-28.
Fonseca, A.M., Pereira, C.F., Porto, G., Arosa, F.A. (2003). Red blood cells upregulate cytoprotective proteins and the labile iron pool in dividing human T cells despite a reduction in oxidative stress. Free Radic. Biol. Med. 35, 1404-1416.
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