Neuroscience and disease


Current research of the Neuroscience and Disease area ranges from investigating the molecular and cellular mechanisms of learning and memory to the regulation of vascular tone by neuronal activity. Researchers at CNC are at the forefront of research into the molecular mechanisms of neurological and psychiatric diseases, including stroke, Parkinson’s disease, Alzheimer’s disease, PolyQ diseases, depression and autism. For that neuroscientists are using established and in-house newly generated animal models of disease, with the expectation that their efforts will lead to new treatment and prevention options. They also combine expertise in the field of molecular biology, biochemistry, cell biology, electrophysiology and imaging.

The main goals are:

  • To understand brain function, from developmental aspects to mechanisms of synaptic plasticity and memory formation, and to the identification of brain regions regulating selective behaviors;
  • To elucidate the molecular mechanisms and the circuit basis of dysfunction in neurodegenerative and neuropsychiatric disease, aiming for the identification of efficient targets for therapy;
  • To design intervention strategies to mitigate brain diseases.
Research labs    
Carlos B. Duarte   Growth Factor Signaling and Brain Ischemia
Irina S. Moreira   Structural, Computational and Chemical Biology
Cláudia Cavadas   Neuroendocrinology and Aging
Rodrigo A. Cunha   Neuromodulation
João Laranjinha   Redox Biology and Brain Sensing
Ana Luísa Carvalho   Synapse Biology
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