The scientific area of New Preventive and Therapeutic Strategies has a focus on translational approaches that span from the study of the biology of pathogens and of infection, to the molecular basis of cancer and neurodegeneration, aiming at developing strategies to modify or block their progression. This is accomplished by coupling the study and understanding of the molecular mechanisms involved in microbial infection, cancer and neurodegenerative diseases, to the knowledge of therapeutic tools, such as nucleic acids, vectors, drugs and pharmacokinetic models.
The main goals are:
- To identify novel targets in microbial metabolism and host membrane trafficking;
- To identify novel cancer targets and impairments in autophagy and proteolysis in neurodegenerative diseases;
- To develop innovative tools for viral and non-viral gene therapy in cancer and brain disorders, nanosystems for cancer targeting and vaccination;
- To develop novel low molecular weight drugs and mathematical models grounded on experimental bioanalytics to predict drug pharmacokinetics.