The core scientific activity of CNC is the study of the molecular basis of neurodegenerative processes common to aging, neurodegenerative disorders, cerebral ischemia and epilepsy. In parallel, the research groups explore mechanisms of neuroprotection and regeneration, which may be future candidates for the development of potential therapeutic strategies to manage these disorders. This core activity is complemented by supporting areas which also develop their own research activity, opening the scope of intervention of CNC in the biomedical field, while providing novel lines of research applicable to Neuroscience, namely: genetic screening of diseases; structure-function relation of proteins with biomedical or biotechnological interest; development of new vectors for delivery of drugs and genetic material; development of biomaterials for stem cell-based therapeutics; study of drug and disease-induced cell dysfunction, with particular expertise in processes involving mitochondrial dysfunction and free radicals; intermediate metabolism and diabetes; cellular and developmental biology, whose programs focused on human infertility, disruption of human cell function in cancer, contact dermatitis, osteoarthritis, autoimmune disease, obesity and pathogens biology, involve close partnerships with clinicians at Coimbra University Hospital Center (CHUC) and Coimbra Portuguese Institute of Oncology (IPO); microbiology with emphasis on the strategies for adaptation of microorganisms to extreme environments, the screening and development of new anti-mycobacterial drugs and the susceptibility to legionella and fungal infection.

Translational research, organized as an Inter-Institutional Research Programme,involves Hospitals, Pharmaceutical Companies and Biocant - Biotechnology Innovation Center. Development of new technologies based on solid fundamental research, and stimulated by the growing interest in translational research, led to reorganization of the services sector and to the creation of a technology transfer unit at Biocant, the UC-BIOTECH. The promotion of technology transfer and the creation of novel biomedical and biotechnology enterprises is one of the aims of CNC at Biocant.
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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