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| Manuela Grazina |
| Ph.D. |
| University of Coimbra |
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Instituto de Bioquímica
Faculdade de Medicina
Pólo III
Subunidade I de Ensino
2º andar, G. 2.31
Azinhaga Sta. Comba Celas
3000-354 COIMBRA
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+351 239 480040 |
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+351 239 480048 |
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| Publications |
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“Atypical presentation of Leber`s hereditary optic neuropathy associated to mtDNA 11778G > A point mutation – A casa report”
Grazina, M.M., Diogo, L., Garcia, P., Silva, E., Garcia, T., Robalo, C., Oliveira, C. 2007.
Eur J Paediatr Neurol 11: 115-118.
“Genetic basis of Alzheimer’s dementia”
Grazina, M., Pratas, J., Silva, F., Oliveira, S., Santana, I., Oliveira, C. 2006.
Genes, Brain and Behaviour 5 (Suppl. 2), 92–107. Review.
“High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene”
Correia, C., Coutinho, A.M., Diogo, L., Grazina, M., Marques, C., Miguel, T.S., Ataíde, A., Borges, L., Oliveira, C., Oliveira, G., Vicente, A.M. 2006.
J Autism Dev Disord. 36(8): 1137-1140.
“Mitochondrial dysfunction in autism spectrum disorders: a population-based study”
Oliveira, G., Diogo, L., Grazina, M., Garcia, P., Ataíde, A., Marques, C., Miguel, T., Borges, L., Vicente, A.M., Oliveira, C.R. 2005.
Develop. Med. & Child. Neurol. 47: 185–189.
“Mitochondrial DNA variants in a Portuguese population of Alzheimer’s patients”
Grazina, M., Silva, F., Santana, I., Pratas, J., Santiago, B., Oliveira, M., Carreira, I., Cunha, L., Oliveira, C. 2005.
Eur. Neurol. 53(3): 121-124.
“Frontotemporal dementia and mitochondrial DNA transitions”
Grazina, M., Silva, F., Santana, I., Santiago, B., Oliveira, M., Cunha, L., Oliveira, C. 2004.
Neurobiol. Dis. 15 (2): 306-311.
“Parkinson’s Disease and Mitochondrial DNA NADH Dehydrogenase Subunit 1 Nucleotides 3337-3340: Study in a Population from the Central Region of Portugal (Coimbra)”
Grazina, M., Silva, F., Januário, C., Oliveira, M., Cunha, L., Oliveira, C. 2003.
Eur. Neurol. 50 (1): 60-61.
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| Curriculum |
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Education:
Ph.D. in Biomedical Sciences, Faculty of Medicine, University of Coimbra (2006)
Post-graduation in Biomedicine, Faculty of Medicine, University of Coimbra (1996)
M.Sc. in Cell Biology, Faculty of Sciences and Techology, University of Coimbra (1994)
Graduation in Biochemistry, Faculty of Sciences and Techology, University of Coimbra (1991)
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Previous and current professional activities:
Assistant Professor, Faculty of Medicine, University of Coimbra (20/06/2006 - present)
Teaching Assistant, Faculty of Medicine, University of Coimbra (09/02/2000 – 19/06/2006)
Invited Teaching Assistant, Faculty of Medicine, University of Coimbra (12/10/1998 - 08/02/2000)
Invited Teaching Assistant (40%), Faculty of Medicine, University of Coimbra (03/03/1997 - 11/10/1998)
Doctoral Fellow (FCT), Centre for Neuroscience nd Cell Biology, University of Coimbra (10/03/1995 – 30/09/1998)
Research Fellow, INSERM U-393, Groupe Hopitalier Necker-Enfants Malades, Paris, France (01/03/1994 – 28/02/1995)
Master Fellow (FCT), Centre for Neuroscience and Cell Biology, University of Coimbra (1992 – 1993)
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| Thesis |
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Genoma Mitocondrial e Défice Energético no Diagnóstico das Doenças da Cadeia Respiratória Mitocondrial/ Mitochondrial Genome and Energetic Deficiency in Diagnosis of Mitochondrial Respiratory Chain Diseases (Tese de Doutoramento/ Ph.D.). Grazina MMM (2006).
Genetic Studies in Schizophrenia and Bipolar Disorder/ Genetic studies in Schizophrenia and Bipolar Disorder. (Tese de Mestrado/ M.Sc.). Grazina MMM (1994).
Grazina MMM (1991). "Mecanismo de oxidação de alguns Alcalóides com propriedades anti-neoplásicas/ Oxidation mechanism of some alchaloids with antineoplasic properties. (Tese de Licenciatura/ Graduation).
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